An RSI Understanding Risk method
Toxicological reference value derivation
Toxicological reference value derivation is one of the methods used by Risk Sciences International to better understand risk.
Broadly
Toxicological reference values—such as reference doses (RfD), acceptable daily intakes (ADI), or tolerable concentrations—define exposure levels considered safe for human or ecological health. These values are derived from experimental data using critical effect selection, point of departure identification, and uncertainty factors. The method provides a cornerstone for quantitative risk assessment, but depends heavily on data quality and conservative judgment.
More specifically
RSI conducts reference value derivation as part of its toxicological and regulatory work. The firm applies established methodologies, transparently selects uncertainty factors, and prepares documentation suitable for regulatory review. RSI ensures that derived values reflect current science and are communicated clearly to support risk-based decision-making.