An RSI Understanding Risk method
Application of new approach methodologies (NAMs)
Application of new approach methodologies (NAMs) is one of the methods used by Risk Sciences International to better understand risk.
Broadly
New Approach Methodologies (NAMs) encompass emerging scientific techniques that supplement or replace traditional risk assessment tools, particularly those involving animal testing. These include in vitro assays, computational modeling, high-throughput screening, and ‘omics’ technologies such as genomics or metabolomics. NAMs are used to generate predictive data about toxicological effects and biological mechanisms. Their advantages lie in ethical considerations, speed, and adaptability to large-scale chemical evaluations. However, challenges remain in validation, regulatory acceptance, and integration into decision-making frameworks that were developed with traditional methods in mind.
More specifically
RSI is well positioned to integrate NAMs into its Understanding Risk methods by aligning scientific innovation with policy realism. RSI’s teams include toxicologists, modelers, and risk analysts with experience in interpreting NAM outputs within weight-of-evidence frameworks. The firm can evaluate the appropriateness of a given NAM for a client’s specific context, help interpret model results, and document methodological decisions in a transparent and policy-ready manner. RSI’s ability to translate novel science into applied insights ensures that NAMs are used effectively and credibly in support of regulatory and advisory functions.