RSI's Daniel Krewski - Official portrait

Dr. Daniel Krewski

FSRA, PhD, MHA

Chief Risk Scientist

Joined RSI in 2006

  • Global thought leader in risk science

  • Expert in public and population health

  • 20+ years experience in Federal Government of Canada

  • Professor of epidemiology at University of Ottawa since 1998

  • Research contributions influencing health policy

Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific leader, Dr. Krewski helped define the company’s ethos and methodological approach, grounded in rigorous, transparent, and policy-relevant science.

Under his leadership, RSI has become an international reference point in risk science, advising public and private sector organizations on issues ranging from chemical exposure and public health to advanced toxicity testing, infectious disease modeling, and environmental protection. He has served as RSI’s scientific anchor across dozens of high-profile engagements—among them, work for the U.S. Environmental Protection Agency, Health Canada, the Alliance of Blood Operators, and the Pan American Health Organization.

Although now retired as CEO, Dr. Krewski continues in his role as Chief Risk Scientist, where he contributes to RSI’s most complex risk assessment mandates and supports long-term innovation in the company’s scientific strategy. His work at RSI continues to bridge regulatory application with academic inquiry, and he remains a prolific contributor to RSI publications and tools, including frameworks for next-generation toxicity testing and comparative risk modeling.

He has played key roles in RSI projects addressing risks as varied as mad cow disease, carbon capture and storage, air pollution, climate change, neurological disorders, and pandemic influenza. Across these efforts, his expertise in quantitative modeling, risk communication, and structured expert judgment has helped shape not just organizational practices, but international standards in risk evaluation.

Dr. Krewski’s ongoing relationship with academic institutions—particularly the University of Ottawa—has allowed RSI to maintain strong ties to research frontiers. His joint appointments foster a model of knowledge transfer that benefits RSI’s clients and contributes to training the next generation of risk scientists through mentorship, graduate education, and real-world project integration.

Pre-RSI

Daniel Krewski’s pioneering role in the field of risk science began well before the discipline gained formal recognition. Trained first in mathematics, then in statistics, and ultimately in biostatistics with applications in toxicology and epidemiology, his career has always been at the intersection of quantitative analysis and human health. This multidisciplinary pathway reflects the inherently integrative nature of modern risk science.

He began his professional journey in the Federal Government of Canada, where he served for over 20 years, primarily within Health Canada. There, he worked across a spectrum of risk-related domains—food safety, environmental health, toxicological risk evaluation—collaborating with bench scientists, regulatory evaluators, legislative advisors, and public policy experts. These experiences shaped his enduring focus on pragmatic, science-based solutions to protect population health.

In 1998, Dr. Krewski joined the University of Ottawa as a Professor in the School of Epidemiology and Public Health, where he quickly distinguished himself as both a teacher and research leader. At the university, he founded the McLaughlin Centre for Population Health Risk Assessment, modeled after the Harvard Center for Risk Analysis. The Centre became a leading institution for Canadian risk science, fostering national and international collaborations and serving as a hub for innovative methods in risk assessment and management.

During this period, Dr. Krewski was instrumental in helping to develop foundational risk assessment frameworks for both Health Canada and the U.S. Environmental Protection Agency. He contributed to the evolution of regulatory risk practice, building on the insights from landmark efforts like the U.S. National Research Council’s “Red Book” and later publications on toxicity testing and comparative exposure analysis.

His academic initiatives included the creation of Canada’s first graduate program in risk science, providing structured education for a new generation of interdisciplinary risk professionals. He also served as scientific lead or co-lead on numerous large-scale research initiatives and policy collaborations, including systematic reviews on neurological disease, lung cancer burden, and chemical health impacts, and helped structure national responses to emerging risks like bovine spongiform encephalopathy (BSE) and chronic wasting disease.

Through these pre-RSI roles, Dr. Krewski laid much of the groundwork for RSI’s eventual founding, bringing a blend of government experience, academic leadership, and global thought leadership that would come to define the firm’s identity.


Daniel Krewski, in addition to his many hours spent teaching at the University of Ottawa, is regularly asked to speak including this presentation given during the National Cancer Institute Directors' meeting in Lyon.

Case studies associated with Daniel Krewski

Environmental Public Health Approach (EPHA) to Chemicals Expert Workshop

PROJECT DESCRIPTION

To advance the Government of Canada’s Chemicals Management Plan (CMP), a virtual expert workshop was planned and hosted to refine and evaluate a Canadian framework for the Environmental Public Health Approach (EPHA) to chemicals. The initiative focused on developing case...
Read More about Environmental Public Health Approach (EPHA) to Chemicals Expert Workshop

Systematic Review of Artificial Sweeteners and Health Risks

PROJECT DESCRIPTION

A comprehensive systematic review was undertaken to assess experimental evidence regarding the potential health risks associated with artificial sweeteners, specifically focusing on cancer and pre-term delivery. The client sought a rigorous analysis of both in vivo and in vitro experimental...
Read More about Systematic Review of Artificial Sweeteners and Health Risks

Evaluation of Health Product Risk Communication Tools

PROJECT DESCRIPTION

To enhance the effectiveness of health product risk communications, a systematic evaluation was requested to assess the performance of key instruments used to disseminate safety and efficacy information. The aim was to support efforts under the Evaluating the Effectiveness of...
Read More about Evaluation of Health Product Risk Communication Tools

Evaluation of Drug Recall Communication and Risk Determination Processes

PROJECT DESCRIPTION

In response to public and ministerial concerns about the timeliness and adequacy of information shared during a major prescription drug recall, Health Canada commissioned an independent review to assess its response to the event. The situation involved a recall of...
Read More about Evaluation of Drug Recall Communication and Risk Determination Processes

Publications associated with Daniel Krewski

Reanalysis of the Harvard Six Cities Study, part II: sensitivity analysis.


ABSTRACT

Following the validation and replication of the Harvard Six Cities Study (Krewski et al., this issue), we conducted a wide range of sensitivity analyses to explore the observed associations between long-term exposure to fine particle or sulfate air pollution and...
Publication details about Reanalysis of the Harvard Six Cities Study, part II: sensitivity analysis.

Effect of short-term exposure to low levels of gaseous pollutants on chronic obstructive pulmonary disease hospitalizations.


ABSTRACT

We examined the associations between gaseous pollutants and hospitalization for chronic obstructive pulmonary diseases (COPD) among elderly people living in Vancouver, British Columbia, Canada, a city in which ambient air pollution levels are relatively low. We regressed the logarithm of...
Publication details about Effect of short-term exposure to low levels of gaseous pollutants on chronic obstructive pulmonary disease hospitalizations.

The effect of censoring on cancer risk estimates based on the Canadian National Dose Registry of occupational radiation exposure.


ABSTRACT

Cohort studies represent an important epidemiological tool for exploring the potential adverse health effects of low-dose exposure to ionizing radiation in the workplace. Analyses of data from the National Dose Registry of Canada have suggested that occupational radiation exposure leads...
Publication details about The effect of censoring on cancer risk estimates based on the Canadian National Dose Registry of occupational radiation exposure.

Decreases in occupational exposure to ionizing radiation among Canadian dental workers.


ABSTRACT

OBJECTIVE: To describe doses of ionizing radiation and their possible associations with mortality rates and cancer incidence among Canadian dental workers. METHODS: The National Dose Registry (NDR) of Canada was used to assess occupational dose of ionizing radiation received by...
Publication details about Decreases in occupational exposure to ionizing radiation among Canadian dental workers.

Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease.


ABSTRACT

BACKGROUND: Epidemiologic studies have linked long-term exposure to fine particulate matter air pollution (PM) to broad cause-of-death mortality. Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality. METHODS AND RESULTS: General pathophysiological...
Publication details about Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease.

Association between particulate air pollution and first hospital admission for childhood respiratory illness in Vancouver, Canada.


ABSTRACT

In this study, the authors assessed the impact of particulate air pollution on first respiratory hospitalization. Study subjects were children less than 3 years of age living in Vancouver, British Columbia, who had their first hospitalization as a result of...
Publication details about Association between particulate air pollution and first hospital admission for childhood respiratory illness in Vancouver, Canada.

Influence of relatively low level of particulate ar pollution on hospitalization for COPD in elderly people.


ABSTRACT

To assess the association between relatively low levels of size-fractioned particulate matter (PM) and hospitalization for chronic obstructive pulmonary disease (COPD), we conducted a time-series analysis among elderly people 65 yr of age or more living in Vancouver between June...
Publication details about Influence of relatively low level of particulate ar pollution on hospitalization for COPD in elderly people.

Managing the microbiological risks of drinking water.


ABSTRACT

The microbiological contamination of drinking water supplies can have serious health consequences for consumers, and this has been dramatically illustrated in recent years by two disease outbreaks in Canada. In this paper, some factors that can influence the microbiological quality...
Publication details about Managing the microbiological risks of drinking water.

Bias due to aggregation of individual covariates in the Cox regression model.


ABSTRACT

The impact of covariate aggregation, well studied in relation to linear regression, is less clear in the Cox model. In this paper, the authors use real-life epidemiologic data to illustrate how aggregating individual covariate values may lead to important underestimation...
Publication details about Bias due to aggregation of individual covariates in the Cox regression model.

Search all publications

RSI News associated with Daniel Krewski

Aging and cognitive decline

Working with the College of Physicians and Surgeons of Alberta, Risk Sciences International conducted a wide-ranging review of aging and cognitive decline, with specific focus on aging physicians and fitness to practice.  The publication in Aging & Mental Health documents domains of cognition that decline with older age, concerns with...
News article about Aging and cognitive decline

Evidence-based Risk Assessment Framework

Working with international thought leaders in risk science, Risk Sciences International investigators contributed to the development of the evidenced-based risk assessment framework shown in the figure below.  The framework evolved from a workshop held at the University of Ottawa in December 2018, jointly organized by the McLaughlin Centre for Population Health Risk...
News article about Evidence-based Risk Assessment Framework

Value of information

Risk Sciences International (RSI) investigators Greg Paoli, Shintaro Hagiwara and Daniel Krewski collaborated with investigators from the US Center for Computational Toxicology and Exposure (CCTE) on the development of an analytical framework to evaluate alternative chemical toxicity testing strategies, meeting a need identified by the US National Research Council in...
News article about Value of information

Quinolones and risk of retinal detachment

Following previous work on the potential risk of acute liver failure associated with quinolone antibiotics, RSI investigators, Mohamed Taher, Franco Momoli, Donald Mattison and Daniel Krewski evaluated the potential risk of retinal detachment (RD) associated with these medications. Although no cases of RD were linked to quinolones in clinical trials, some...
News article about Quinolones and risk of retinal detachment

Bias Assessment in Case-Control and Cohort Studies for Hazard Identification

IARC recently published a volume on quantitative bias modelling: Bias assessment in case–control and cohort studies for hazard identification (IARC Scientific Publication No. 171). We are pleased to see inclusion of some of the work RSI's Drs Franco Momoli and Daniel Krewski conducted for the INTERPHONE and MOBI-Kids studies of...
News article about Bias Assessment in Case-Control and Cohort Studies for Hazard Identification

Outside RSI

Beyond his extraordinary professional accomplishments, Dr. Daniel Krewski is a passionate mentor, energetic speaker, and multitalented individual with a strong connection to both scientific and civic life. Over the course of his career, he has supervised dozens of graduate students and postdoctoral researchers, many of whom have gone on to lead public health, environmental safety, and risk science programs across Canada and internationally.

He remains deeply engaged in the academic community as Scientific Director of the McLaughlin Centre and as a senior member of faculty at the University of Ottawa, where he contributes to program development, scientific advisory boards, and expert panels. He frequently participates in peer-review committees, conference keynote sessions, and collaborative projects with regulatory and research agencies worldwide.

Known for his clarity of thought and collegial manner, Dr. Krewski is often described by colleagues as a principled scientist—someone who communicates with humility, leads through consensus, and uses evidence to advance public well-being.

Yet his interests are far from limited to risk science.

He is a prolific amateur photographer, responsible for documenting RSI’s visual history and for capturing many of the natural stone sculptures and other imagery featured on RSI’s materials and website. His love of photography reflects a lifelong attention to detail and composition—qualities that mirror his scientific mindset.

A resident of Ottawa, Dr. Krewski also enjoys wine tasting, stone sculpture, and performance driving, having participated in programs such as the Ford Performance Racing School in North Carolina. He is equally at home leading a Zumba class on Parliament Hill as he is reviewing national environmental policy; his personal vitality and balance make him a compelling presence across settings.

Through these extracurricular pursuits, Dr. Krewski brings humanity, curiosity, and creativity to everything he does—reinforcing his role not only as a global thought leader in risk science but as a vibrant contributor to Canada’s cultural and academic life.

Teaching Zumba with Co-instructors Sharon and Iryna

A few more images...