Natalia (Natasha) Shilnikova

MD, PhD

Senior Health Risk Analyst

Joined RSI in 2011

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RSI's Natalia (Natasha) Shilnikova

Personal Introduction

I earned my first professional degree in Medicine from Perm State Medical Institute, now Perm State Medical Academy (Perm, Russia), and a PhD in Medical Sciences from the State Research Center Institute of Biophysics, now the Federal Medical Biophysics Center of the Federal Medico-Biological Agency (FMBA) of the Russian Federation. I worked for many years at the Laboratory of Epidemiology of the Southern Ural Biophysics Institute (Ozyorsk, Russia). My primary responsibility involved the analysis of mortality and cancer incidence in the cohort of workers at the Russian nuclear complex Mayak and in the population living near the nuclear facility. My work was largely supported by contracts with the U.S. National Cancer Institute and the U.S. Department of Energy. I moved to Canada in 2007 and joined the University of Ottawa McLaughlin Centre for Population Health Risk Assessment. At the McLaughlin Centre, I worked on several projects related to the assessment of health risks from physical, chemical and biological agents. I joined RSI in December 2011.

Natasha Shilnikova and RSI staff at work

Natasha Shilnikova at the international expert panel workshop organized by RSI and the International Manganese Institute (IMnI)

Natalia (Natasha) Shilnikova: Current Focus

At RSI, Dr. Natalia (Natasha) Shilnikova has been working on projects involving toxicology, epidemiology and human health risk assessment, such as development of toxicity profiles for several chemicals on Health Canada’s Domestic Substances List (DSL); a systematic review of potential cancer and reproductive risks of artificial sweeteners for the International Prevention Research Institute (IPRI) of Lyon, France; a comprehensive review of the literature related to the human health effects of manganese for the International Manganese Institute (IMnI); evidence synthesis on post-approval surveillance of novel cancer drugs, factors associated with abnormal call rate in breast cancer screening, cancer risks associated with cannabis use for the Canadian Partnership against Cancer (CPAC); a clinical drug review of botulinum toxin for the Workplace Safety Insurance Board (WSIB).

Works and Accomplishments

Selected Reports

 
Dr. Shilnikova is a co-author of the following (selected) reports.
 

  • Developing Revised Diagnostic Criteria for Manganism: Systematic Review of Pharmacokinetics of Manganese compounds. Report prepared for the International Manganese Institute. May 2020.
  • Clinical Drug Review for WSIB Formulary Consideration. Botulinum Toxin. Prepared for Workplace Safety Insurance Board. May 2019.
  • Rapid Review of Evidence on Cannabis Use and Cancer Risk. Prepared for Canadian Partnership Against Cancer. March 2019.
  • Evidence Synthesis on Factors Associated with Abnormal Call Rate in Breast Cancer Screening. Report prepared for Canadian Partnership Against Cancer. June 2018
  • Ethical Considerations in Risk Assessment. Background Paper prepared for Health Canada Workshop on Ethics in Risk Assessment. March 2018
  • Reproductive and Endocrine Effects Associated with Parabens. Report prepared for Health Canada. April 2018
  • Academic literature search for international colorectal cancer screening indicators. Report prepared for Canadian Partnership Against Cancer. October 2017
  • Exposure Information Gathering for CMP3 Flame Retardant Substances. Report prepared for Health Canada. August 2017
  • Human Health Risk Assessment of Aluminum in Drinking Water. Report prepared for Health Canada. March 2016
  • Evidence Synthesis on Post-Approval Surveillance of Approved Novel Cancer Drugs. Report prepared for Canadian Partnership against Cancer. 8 January 2016
  • Review of Regulations Regarding Fluoride in Drinking Water and Authoritative Reviews of Scientific Literature. Report prepared for Rio Tinto Alcan, Héritage Industriel / Legacy Management Europe. 10 April 2015
  • Artificial Sweeteners and the Risk of Cancers and Pre-Term Delivery: A Systematic Review of Experimental Studies. Prepared for the International Prevention Research Institute (IPRI). September 2014.
  • Identification and Review of the Recent (2009-June 2013) Scientific Literature Relevant to the Human Risk Assessment for Mn & its Inorganic Compounds. Prepared for the International Manganese Institute. October 2014.
  • ESSA Technologies, J. Laurence, Risk Sciences International, Trent University, and Trinity Consultants. 2014. Kitimat Airshed Emissions Effects Assessment. Report prepared for BC Ministry of Environment, Smithers, BC. 205 pp. + appendices.
    • http://www.bcairquality.ca/airsheds/docs/ESSA-Kitimat-Airshed-Report_20140425.pdf
  • ESSA Technologies, J. Laurence, Limnotek, Risk Sciences International, Rio Tinto Alcan, Trent University, Trinity Consultants, and University of Illinois. 2013. Sulfur Dioxide Technical Assessment Report in Support of the 2013 Application to Amend the P2-00001 Multimedia Permit for the Kitimat Modernization Project. Draft for Consultations. Volume 1: Executive Summary. Prepared for Rio Tinto Alcan, Kitimat, B.C . 37pp. https://www.documentcloud.org/documents/1030053-sulphur-dioxide-technical-assessment.html
  • EPA’s Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments, Volume 1. In Support of Summary Information on the Integrated Risk Information System (IRIS). February 2012. http://cfpub.epa.gov/ncea/iris/iris_documents/documents/supdocs/dioxinv1sup.pdf

Selected Publications

  • Kadry Taher M, Farhat N, Karyakina NA, Shilnikova N, Ramoju S, Gravel CA, et al. Critical review of the association between perineal use of talc powder and risk of ovarian cancer. Reproductive toxicology (Elmsford, NY). 2019;90:88-101.
  • Ramoju S, Andersen ME, Nong A, Karyakina N, Shilnikova N, Krishnan K, et al. Derivation of whole blood biomonitoring equivalents for titanium for the interpretation of biomonitoring data. Regulatory toxicology and pharmacology: RTP. 2020;114:104671.
  • Ramoju S, Andersen M, Poddalgoda D, Nong A, Karyakina N, Shilnikova N, et al. Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data. Regulatory toxicology and pharmacology : RTP. 2020;111:104581.
  • Ramoju SP, Mattison DR, Milton B, McGough D, Shilnikova N, Clewell HJ, et al. The application of PBPK models in estimating human brain tissue manganese concentrations. Neurotoxicology. 2017;58:226-37.
  • Milton B, Krewski D, Mattison DR, Karyakina NA, Ramoju S, Shilnikova N, et al. Modeling U-shaped dose-response curves for manganese using categorical regression. Neurotoxicology. 2017;58:217-25.
  • Shilnikova NS, Habash RWY, Turner MC, Zielinski JM, Krewski D. Causes of Breast Cancer: Ionising and Non-Ionising Radiation. World Breast Cancer Report 2012. International Prevention Research Institute, Lyon, France. 2012. Chapter 19, pp. 185-195.
  • Duport P, Jiang H, Shilnikova NS, Krewski D, Zielinski JM. Database of radiogenic cancer in experimental animals exposed to low doses of ionizing radiation. Journal of toxicology and environmental health Part B, Critical reviews. 2012;15(3):186-209.
  • Crump KS, Duport P, Jiang H, Shilnikova NS, Krewski D, Zielinski JM. A meta-analysis of evidence for hormesis in animal radiation carcinogenesis, including a discussion of potential pitfalls in statistical analyses to detect hormesis. Journal of toxicology and environmental health Part B, Critical reviews. 2012;15(3):210-31.
  • Shilnikova NS, Krewski D, Tyshenko MG. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease risk management in Nordic countries. International Journal of Risk Assessment and Management. 2010;14(3-4):284-303.
  • Shilnikova NS, Krewski D, Tyshenko MG. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease risk management in Belgium. International Journal of Risk Assessment and Management. 2010;14(3-4):179-91.
  • Shilnikova NS, Krewski D, Tyshenko MG. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease risk management in Spain. International Journal of Risk Assessment and Management. 2010;14(1-2):145-56.
  • Shilnikova NS, Krewski D, Tyshenko MG. Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease risk management in the Netherlands. International Journal of Risk Assessment and Management. 2010;14(3-4):192-202.
  • Tyshenko MG, Farhat N, Lewis R, Shilnikova N, Krewski D. Applying a precautionary risk management strategy for regulation of nanotechnology. International Journal of Nanotechnology. 2010;7(2-3):243-64.
  • Zielinski JM, Garner MJ, Band PR, Krewski D, Shilnikova NS, Jiang H, et al. Health outcomes of low-dose ionizing radiation exposure among medical workers: a cohort study of the Canadian national dose registry of radiation workers. International journal of occupational medicine and environmental health. 2009;22(2):149-56.
  • Zielinski JM, Ashmore PJ, Band PR, Jiang H, Shilnikova NS, Tait VK, et al. Low dose ionizing radiation exposure and cardiovascular disease mortality: cohort study based on Canadian national dose registry of radiation workers. International journal of occupational medicine and environmental health. 2009;22(1):27-33.
  • Zielinski JM, Shilnikova NS, Krewski D. Canadian National Dose Registry of radiation workers: overview of research from 1951 through 2007. International journal of occupational medicine and environmental health. 2008;21(4):269-75.
  • Sokolnikov ME, Gilbert ES, Preston DL, Ron E, Shilnikova NS, Khokhryakov VV, Vasilenko EK, Koshurnikova NA. Lung, liver and bone cancer mortality in Mayak workers. Int J Cancer. International journal of cancer. Journal international du cancer. 2008; 123(4):905-911.
  • Shilnikova N, Preston D, Okatenko P, Gilbert E, Ron E, Sokolnikov M, Kuznetsova I, Khokhryakov V, Vassilenko E, Koshurnikova N. Mayak worker mortality: Overview and site-specific risks. [Journal: Conference Paper] Radiation Research. 2007; 167(3): 352-353.
  • Gilbert ES, Sokolnikov ME, Shilnikova NS, Preston DL, Ron E, Okatenko PV, Khokhryakov VF, Vassilenko EK, Koshurnikova NA. Mayak worker study: Risks of lung, liver and bone cancer from plutonium. [Journal: Conference Paper] Radiation Research. 2007; 167(3): 353-354.
  • Koshurnikova NA, Sokolnikov ME, Shilnikova NS, Rogacheva SA, Filippova LG, Okatenko PV, Kuznetsova IS, Bolotnikova MG. (2005). Late health effects of incorporation of plutonium compounds in man. In: Ilyin L.A., Kochetkov O.A., Romanov S.A., eds, Plutonium. Radiation safety. Moscow, IzdAT, pp. 373-398 [in Russian]
  • Shilnikova NS, Preston DL, Ron E, Gilbert ES, Vassilenko EK, Romanov SA, et al. Cancer mortality risk among workers at the Mayak nuclear complex. Radiation research. 2003;159(6):787-98.
  • Koshurnikova NA, Mushkacheva GS, Shilnikova NS, Rabinovich EI, Petrushkina NP, Hall P, et al. Studies on the Ozyorsk population: health effects. Radiation and environmental biophysics. 2002;41(1):37-9.
  • IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 78 “Ionizing Radiation, Part 2: Some Internally Deposited Radionuclides”. Section 2.4.3 “Plutonium. Russian Federation”. IARC Press, Lyon, France, 2001.

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