Nataliya Karyakina

PhD, MSc, BSc

Senior Toxicologist, Health Risk Analyst

Joined RSI in 2008

  • Canada

    Country of Residence

Nataliya Karyakina

Personal Introduction

In 1983, I graduated from the Kiev State Medical Institute named after O.O. Bogomolets (now, Bogomolets National Medical University), where I obtained a B.Sc. in Medicine and a M.Sc. in Epidemiology. In 1992, I earned a Ph.D. in Toxicology at Ukrainian Scientific and Research Institute of Pharmacology and Toxicology, Ministry of Public Health of Ukraine (Kiev, Ukraine). While working on my dissertation, I examined hazardous properties of a new plant growth regulator (PGR) from nicotinic acid (niacin or vitamin B3) derivatives and its structural analogs to establish the Maximum Allowable Concentration (MAC) of the new PGR in surface water, used as drinking water supply by the general population. After defending my dissertation, I joined the Scientific Research Institute of Hygiene and Toxicology of Pesticides, Polymers and Plastics, Ministry of Public Health of the Soviet Union (Kiev, Ukraine) (currently, Scientific Centre of Preventive Toxicology, Food and Chemical Safety, Ministry of Public Health of Ukraine). My primary responsibilities included:

  • identification and assessment of acute, sub-chronic and chronic toxicity of new chemical substances and compounds from various chemical groups;
  • investigation of accumulation properties of new chemicals and it metabolites in biological tissues and organs of laboratory animals and environmental media;
  • analysis of the metabolism, toxicokinetic and potential mode of action of new chemicals and its potential metabolites;
  • identification of critical adverse health effect(s);
  • justification of the lowest observed adverse effect levels (LOAELs) and the no-observed-adverse-effect-levels (NOAELs) of acute, sub-acute and chronic toxic effects following oral, inhalation or dermal exposure;
  • investigation of environmental fate of new chemicals and its metabolites, their stability in drinking water and dependence of these indices on environmental conditions;
  • preparation of rationale documents for the development of regulatory health-based safety limits – the maximum acceptable concentrations (MACs) in different environmental media (food products, drinking water, ambient air and soil);
  • preparation of recommendations for the safe use of pesticides for workers and the general public and presentation of these recommendations to the Ministry of Public Health for approval.

I joined the McLaughlin Centre for Population Health Risk Assessment (Institute of Population Health, University of Ottawa) in 2005. At the McLaughlin Centre, I worked on various projects related to the assessment of health risks associated with exposure to physical, chemical and biological infectious agents. I joined RSI in June 2008.

VLUU L100, M100  / Samsung L100, M100

Nataliya, presenting a poster during a workshop.

Nataliya Karyakina: Current Focus

Dr. Nataliya Karyakina has solid knowledge and extensive experience in hazard identification and human health risk assessments of toxic chemicals present in air, water, food and consumer products. Her research focuses on multidisciplinary studies of potential adverse health effects of essential and toxic metals (e.g., aluminium, cooper, lanthanum, lithium, manganese, silica, tellurium), pharmaceuticals (e.g., statins, ethinyl estradiol, estradiol, veterinary drugs), engineered nanomaterials (e.g., titanium dioxide, alumina, nanostructured synthetic amorphous silica), pharmacokinetics and toxicokinetics of environmental, endogenous and man-made endocrine active or disrupting chemicals (e.g., phytoestrogens, estradiol, bisphenol A) (Mattison et al., 2014),research and development of toxicity profiles for chemicals on Health Canada’s Domestic Substances List (DSL) (e.g., carbon black, phthalates, brominated flame retardants). Dr. Karyakina has been working on projects involving classification and labeling of chemicals according to CLP (EC) 1272/2008), derivation of health-based Derived No Effect Levels (DNELs) for workers and the general population according to REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) Regulation (EC 1907/2006) (Armstrong et al., 2020 and Willhite et al., 2020), and derivation of health-based regulatory guidance and values of hazardous chemicals for the general population (Ramoju et al., 2020 a,b). Dr. Karyakina has been involved in a systematic review of the potential carcinogenic hazard associated with a perineal use of talc by the general population (Taher et al., 2019, 2020), a systematic reviews of potential health and environmental risks associated with insoluble and soluble aluminum compounds (Willhite et al., 2014; Willhite et al., 2019), a comprehensive review of the literature related to the potential human health effects of manganese (Mn) and its neurotoxic outcomes following occupational inhalation exposure to manganese (Mattison et al., 2017, Milton et al., 2017). Currently, she is working on projects related to potential adverse health effects following occupational and consumers’ exposure to engineered nanoalumina, on review of the literature related to the current status of diagnostic criteria for occupational manganism in Mn-exposed workers, potential biomarkers of Mn exposure and effects.

Works and Accomplishments

Dr. Karyakina has, to date, authored or co-authored 18 publications in scientific journals.

Armstrong, V., Karyakina, N.A., Nordheim, E., Arnold, I., Krewski, D. 2020. Intent and Provision of REACH: Issues involved in the registration of metals. Neurotoxicology. 2020 Feb 10. [Epub ahead of print].

Willhite, C., Karyakina, N.A., Nordheim, E., Arnold, I.M.F., Armstrong, V., Momoli, F., Shilnikova, N.S., Yenugadhati, N., Krewski, D., Willhite, C.C. 2020. The REACH Process: A case study of aluminium metal, aluminium oxide, and aluminium hydroxide. Neurotoxicology. [accepted for publication].

Ramoju, S., Andersen, M., Poddalgoda, D., Nong, A., Karyakina, N., Shilnikova, N., Krishnan, K., Krewski, D. 2020a. Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data. Regul Toxicol Pharmacol. 2020 Jan 11. [Epub ahead of print].

Ramoju, S., Andersen, M.E., Nong, A., Karyakina, N.A., Shilnikova, N., Krishnan, K., Krewski, D. 2020b. Derivation of whole blood biomonitoring equivalents for titanium for the interpretation of biomonitoring data. Regul Toxicol Pharmacol. 2020 Apr 30. [Epub ahead of print].

Taher, M.K., Farhat, N., Karyakina, N.A., Shilnikova, N., Ramoju, S., Gravel, C.A., Krishnan, K., Mattison, D., Wen, S.W., Krewski, D. 2020. Data on systematic review and meta-analysis of epidemiologic evidence on the association between perineal use of talc powder and risk of ovarian cancer. Data Brief. 29:105277.

Taher., K.M, Farhat, N., Karyakina, N.A., Shilnikova, N., Ramoju, S., Grave, l C.A., Krishnan, K., Mattison, D., Wen, S.W., Krewski, D. 2019. Critical review of the association between perineal use of talc powder and risk of ovarian cancer. Reprod Toxicol. 90: 88-101.

Mattison, D.R., Milton, B., Krewski, D., Levy, L., Dorman, D.C., Aggett, P.J., Roels, H.A., Andersen, M.E., Karyakina, N.A., Shilnikova, N., Ramoju, S., McGough, D. 2017. Severity scoring of manganese health effects for categorical regression. Neurotoxicology. 58:203-216.

Milton, B., Krewski, D., Mattison, D.R., Karyakina, N.A., Ramoju, S., Shilnikova, N., Birkett, N., Farrell, P.J., McGough, D. 2017. Modeling U-shaped dose-response curves for manganese using categorical regression. Neurotoxicology. 58:217-225.

Mattison, D.R., Karyakina, N.A., Goodman, M., LaKind, J.L. 2014. Pharmaco – and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps. Critical Reviews in Toxicology. 6:1-29.

Willhite, C.C., Karyakina, N.A., Yokel, R.A., Momoli, F., Yenugadhati, N., Wisniewski, T.M., Arnold, I.M.F. & Krewski, D. 2014. Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxide, aluminium hydroxide and the soluble salts. Critical Reviews in Toxicology. 44(S4): 1–80.

Willhite, C., Karyakina, N.A., Wiles, A., Yenugadhati, N., Momoli, F., Wisniewski, T., and Krewski D. 2019. Overview of Potential Aluminium Health Risks. Encyclopedia of Environmental Health. 2nd ed. J.O. Niagu, S. Kacew, T. Kawamoto, J.A. Patz and D.M. Rennie, Eds., pp. 817-830. Elsevier, Amsterdam.

Phillips, K.P., Foster, W.G., Leiss, W., Sahni, V., Karyakina, N., Turner, M.C., Kacew, S., Krewski, D. 2008. Assessing and managing risks arising from exposure to endocrine-active chemicals and endocrine toxicants with emphasis on human health risks. Journal of Toxicology and Environmental Health, Part B: Special Issue on Endocrine Toxicants and Human Health Risks. 11(3-4): 351-372.

Momoli, F., Karyakina, N., Dennis, J., Farhat, N., Krewski, D. 2008. Chrysotile asbestos exposure in Canada. Risk Sciences International. 129 p.

Karyakina, N., Darshan, S., Krewski, D. and Tyshenko, M.G. 2010. Bovine spongiform encephalopathy and variant Creutzfeldt-Jacob disease preventive risk management in Russian Federation. International Journal of Risk Assessment and Management. 14 (1/2): 61-79.

Karyakina, N., Krewski, D. and Tyshenko, M.G. 2010. Bovine spongiform encephalopathy and variant Creutzfeldt-Jacob disease risk management in Central European Countries: Czech Republic, Slovakia, Slovenia and Poland. International Journal of Risk Assessment and Management. 14 (1/2):79-103.

Darshan, S., Karyakina, N., Krewski, D. and Tyshenko, M.G. 2010. Preventive risk management strategies for bovine spongiform encephalopathy and variant Creutzfeldt-Jacob disease in India. International Journal of Risk Assessment and Management. 14 (3/4):239-254.

Lemyre, L., Boutette, P., Karyakina, N., Markon, M. P. L., Brazeau, I., Krewski, D. 2009. International case studies of psychosocial ripple effects of Bovine Spongiform Encephalopathy (BSE) in European countries. Journal of Toxicology and Environmental Health, Part A Current Issues. Prion Research in Perspective.72 (17&18):1092-1095.

Lemyre, L., Clément, M., Corneil, W., Craig, L., Boutette, P., Tyshenko, M. G., Karyakina, N., Clarke, R., Krewski, D. GAP-Santé Research Team. 2005. A Psychosocial risk assessment and management framework to enhance response to CBRN terrorism threats and attacks. Biosecurity and Bioterrorism: Biodefense Strategy, Practice and Science. 3(4):316-330.

Karyakina (Minakova) N.A. 1992. Toxicology of new plant growth regulators from nicotinic acid derivates and regulations on their safe application for the public and the environment. Ph.D. Thesis. 14.00.20 – Toxicology. Ukrainian Scientific and Research Institute of Pharmacology and Toxicology, Ministry of Public Health of Ukraine, Kiev, Ukraine. 15 p. [in Russian].

Nataliya Karyakina: Extra-curricular

Nataliya enjoys cooking, reading, mushroom hunting and fishing.

She believes strongly that cooking a favorite dish or learning a recipe for her family and friends is highly rewarding and a continuous learning process.

This quote sums up her passion for books: “I read, so I can live more than one life in more than one place” (Anne Tyler).

Finally, mushroom hunting and fishing provide an amazing opportunity to interact with nature and wildlife.

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Martin LeBlanc

Mr. Martin LeBlanc is responsible for growing RSI’s book of business, supporting all activities to this end. His line is always open to assist clients old and new. He strives to understand and provide a client’s unique need on a project, having done so for many government and private clients across the health, nuclear, power generation, aerospace, manufacturing, transportation and national defence sectors.

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Hong Duan

Since joining RSI’s technical team in 2011, Hong has focused on developing risk-based database-driven web projects. Her extensive knowledge and experience, has helped RSI to develop high quality software for multiple clients including the Public Health Agency of Canada, the U.S. Food and Drug Administration, the Food and Agriculture Organization of the United Nations based in Rome, and the World Health Organization based in Geneva.

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Siva Ramoju

Siva Ramoju holds Masters Degrees in Biotechnology as well as Cellular Toxicology. His previous and present work in cellular toxicology has provided him with training and research experience in understanding how chemicals can damage individual cells, and an understanding of toxicity from the perspective of the whole animal.

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Todd Ruthman

Todd Ruthman’s current focus is on tools that help regulators visualize and understand the public risk burden within their mandates to help inform risk-based decisions. Mr. Ruthman provides design, management, modelling, coding, and database development expertise for these tools. Mr. Ruthman also manages the RSI development group enhancing previously released tools…

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Franco Momoli

Dr. Momoli is the acting Practice Lead for Chemical and Product Safety at Risk Sciences International, as well as an adjunct professor in the School of Epidemiology and Public Health at the University of Ottawa.

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Emma Hartnett

Dr. Hartnett currently works on the development of risk-based decision-making processes and tools to support public risk assessment. Current focus includes: working with the Canadian Food Inspection Agency exploring methodologies to support risk-based monitoring of contaminants in food; working with Transport Canada to develop guidelines and methodologies to support risk-based decisions related to public risks from the transportation system; working with the U.S. Food and Drug Administration on continuing expansions and improvements to the FDA-iRISK tool.

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Donald Mattison

Dr. Donald Mattison was appointed Chief Medical Officer and Senior Vice President of Risk Sciences International in 2012. Dr. Mattison also serves as Associate Director of the McLaughlin Centre for Population Health Risk Assessment and as Adjunct Professor at the School of Epidemiology and Public Health at the University of Ottawa. He is also Medical Advisor to QuarterWatch: Monitoring FDA MedWatch Reports published by the Institute for Safe Medication Practices in Horsham, Pennsylvania.

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Cemil ‘Jim’ Alyanak

Now serving as RSI’s Vice-President Communications and Strategic Initiatives, for years Cemil has provided organizations with guidance designed to transmit mission-critical messages. An anti-tobacco campaign is not about promoting a strategy, it’s about saving lives. Get the message wrong and people die. That type of commitment to results is what Cemil brings to Risk Sciences International.

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Anne Wiles

For her work at RSI, Anne has built on her previous experience and academic research through work on communication on nuclear power and nuclear waste disposal; developing communication strategies and messaging on health risk issues; and delivering training on risk communication. She has also applied her familiarity with risk regulation in many projects on government…

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Greg Paoli

As RSI’s Principal Risk Scientist and COO, Greg Paoli is currently working with a broad spectrum of clients in the public and private sectors, with the greatest emphasis on the development of new approaches to transform regulatory systems to be more “risk-based” at multiple levels: how senior decision-makers process risk information and make the “tough choices” in regulating health and safety, how an organization can optimize its resources across a diverse mandate to maximize total “portfolio-level” risk reduction, and how to operationalize key resources like the scheduling of inspections when faced with thousands of inspection targets, but not enough resources to inspect all of them.

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Jennifer Go

Jennifer joined RSI in August of 2017 as a Risk Analyst with specialization in epidemiology. She possesses a diverse set of skills that contributes to her flexibility to work on a wide range of scientific projects. In particular, Jennifer has research experience in programming using SAS, manipulating large datasets, constructing statistical models, interpreting quantitative data, …

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Michael G. Tyshenko

Dr. Tyshenko is involved with various health risk issues and is the lead on chemical peer reviews at RSI. He continues international research on infectious disease health policy and evidence-based decision-making for SARS, MERS and COVID-19 with a collaborative working group from China, USA, and the UAE. Other ongoing work in Nepal with the Ministry of Health in collaboration…

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Natalia (Natasha) Shilnikova

At RSI, Dr. Natalia (Natasha) Shilnikova has been working on projects involving toxicology, epidemiology and human health risk assessment, such as development of toxicity profiles for several chemicals on Health Canada’s Domestic Substances List (DSL); a systematic review of potential cancer and reproductive risks of artificial sweeteners for the International…

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Daniel Krewski

Dr. Krewski serves as Chief Risk Scientist and CEO of Risk Sciences International. He also holds academic appointments as Professor in the School of Epidemiology and Public Health and Scientific Director of the McLaughlin Centre for Population Health Risk Assessment in the Faculty of Medicine at the University of Ottawa. Dr. Krewski is a Fellow of the Society of Risk Analysis and the American Statistical Association, and a lifetime National Affiliate of the US National Academy of Sciences. In 2013, he received the Distinguished Achievement Award from the Society for Risk Analysis, for excellent performance in the practice of risk analysis. He has contributed to over 900 scientific and technical publications in the field of risk science during the course of his career to date.

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