RSI Expert-Mustafa Al.png-Zoughool

Dr. Mustafa Al-Zoughool

PhD, MSc

Senior Toxicologist

Joined RSI in 2024

  • Highly respected, trusted, and recognized professional with a cross-continental career

  • Assisted in launching two Master programs in Saudi Arabia and Kuwait

  • Vice Dean Academic Affairs for 4 years in the College of Public Health at Kuwait University

Dr. Al-Zoughool has maintained a long-standing relationship with Risk Sciences International, both as a scientific collaborator and as a co-investigator on complex international projects. His work with RSI focuses on high-level public health risk modeling, mechanistic data analysis, and toxicological risk assessment of major environmental contaminants in air, soil, and water, including formaldehyde, lead, and 1,4-dioxane. His research also extends to methodological innovation and the development of evidence-based strategies for environmental and occupational health policy.

His collaborations with RSI have encompassed diverse domains, including the health effects of air pollution, derivation of points of departure for carcinogenic risk assessment, exposure-based toxicokinetic modeling, occupational asthma, disease burden estimation, and quantitative modeling of emerging infectious diseases. He is a frequent contributor to RSI’s global research initiatives, including projects on carcinogen characterization, risk prioritization under climate change, and population health scenario modeling.

Pre-RSI

Dr. Mustafa Al-Zoughool earned his MSc in Analytical Toxicology from the University of Jordan and his PhD in Toxicology from the University of Cincinnati in the United States, where his doctoral research focused on the molecular pathways of chemical-induced carcinogenesis.

He subsequently joined the International Agency for Research on Cancer (IARC) as a postdoctoral fellow, where he led a study examining the relationship between cigarette smoking and the risk of endometrial cancer. Later, at the McLaughlin Centre for Population Health Risk Assessment at the University of Ottawa, Dr. Al-Zoughool led several multidisciplinary projects spanning molecular toxicology, cancer epidemiology, mathematical modeling of prion diseases, and population health risk assessment.

His career has also included academic appointments at universities in Saudi Arabia and Kuwait, where he taught courses in biology, toxicology, environmental health, and infectious diseases, and supervised numerous graduate research projects in environmental health risk assessment. At both institutions, he played a key role in establishing new master’s programs in public health.

Presenting a poster in the same Prion2007 conference in Edinburgh, Scotland.

Mustafa Al-Zoughool at work

Publications associated with Mustafa Al-Zoughool

A framework for the next generation of risk science.


ABSTRACT

OBJECTIVES: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. METHODS: The NexGen framework was built on three cornerstones: the availability of new data on toxicity...
Publication details about A framework for the next generation of risk science.

Risk of endometrial cancer in relationship to cigarette smoking: results from the EPIC study.


ABSTRACT

Current epidemiologic evidence indicates that cigarette smoking reduces the risk of endometrial cancer. We examined data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to analyze further aspects of the smoking-endometrial cancer relationship, such as possible modifying...
Publication details about Risk of endometrial cancer in relationship to cigarette smoking: results from the EPIC study.

4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction conditions and characterization of the UDP-glucuronosyltransferase isoforms.


ABSTRACT

4-Aminobiphenyl (4-ABP) is an arylamine that has long been associated with human and animal urinary bladder cancer. N-glucuronidation is an important metabolic pathway that contributes significantly to 4-ABP-bladder carcinogenesis by facilitating transport of the active metabolites from the liver to...
Publication details about 4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction conditions and characterization of the UDP-glucuronosyltransferase isoforms.

High-performance liquid chromatography method for determination of N-glucuronidation of 4-aminobiphenyl by mouse, rat, and human liver microsomes.


ABSTRACT

A simple and sensitive method for determination of the N-glucuronidation activity of mouse, rat, and human liver microsomes toward the carcinogenic arylamine 4-aminobiphenyl (4-ABP) using high-performance liquid chromatography with ultraviolet detection has been developed. The method uses chemically synthesized 4-ABP-N-glucuronide...
Publication details about High-performance liquid chromatography method for determination of N-glucuronidation of 4-aminobiphenyl by mouse, rat, and human liver microsomes.

A Bayesian back-calculation method to estimate the risk of bovine spongiform encephalopathy (BSE) in Canada during the period 1996-2011.


ABSTRACT

Seventeen typical cases of bovine spongiform encephalopathy (BSE) were detected in Canada the period of 2003-2011. The clinical incidence of BSE was censored by early slaughter, death, or exportation of infected cattle due to the long incubation period of BSE...
Publication details about A Bayesian back-calculation method to estimate the risk of bovine spongiform encephalopathy (BSE) in Canada during the period 1996-2011.

Air Pollution and Respiratory Hospital Admissions in Kuwait: The Epidemiological Applicability of Predicted PM(2.5) in Arid Regions.


ABSTRACT

Dust is a major component of fine particulate matter (PM(2.5)) in arid regions; therefore, concentrations of this pollutant in countries such as Kuwait exceed air quality standards. There is limited understanding on the impact and burden of high PM(2.5) concentrations...
Publication details about Air Pollution and Respiratory Hospital Admissions in Kuwait: The Epidemiological Applicability of Predicted PM(2.5) in Arid Regions.

Using a stochastic continuous-time Markov chain model to examine alternative timing and duration of the COVID-19 lockdown in Kuwait: what can be done now?


ABSTRACT

BACKGROUND: Kuwait had its first COVID-19 in late February, and until October 6, 2020 it recorded 108,268 cases and 632 deaths. Despite implementing one of the strictest control measures-including a three-week complete lockdown, there was no sign of a declining...
Publication details about Using a stochastic continuous-time Markov chain model to examine alternative timing and duration of the COVID-19 lockdown in Kuwait: what can be done now?

Modeling the effect of lockdown timing as a COVID-19 control measure in countries with differing social contacts.


ABSTRACT

The application, timing, and duration of lockdown strategies during a pandemic remain poorly quantified with regards to expected public health outcomes. Previous projection models have reached conflicting conclusions about the effect of complete lockdowns on COVID-19 outcomes. We developed a...
Publication details about Modeling the effect of lockdown timing as a COVID-19 control measure in countries with differing social contacts.

Identification of public health priorities, barriers, and solutions for Kuwait using the modified Delphi method for stakeholder consensus.


ABSTRACT

The rapid modernization and economic developments in Kuwait, have been accompanied by substantial lifestyle changes such as unhealthy diet and physical inactivity. These modifiable behaviours have contributed to increased rates of non-communicable diseases including diabetes and cardiovascular diseases. Delphi Consensus...
Publication details about Identification of public health priorities, barriers, and solutions for Kuwait using the modified Delphi method for stakeholder consensus.

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Outside RSI

Mustafa is an avid traveler with a strong passion for exploring new places and cultures. He has a deep appreciation for nature and enjoys spending quality time with his family, taking long hikes, jogging, fishing, and camping.

At Alhambra Palace, Granada, Spain back in October 2008

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