RSI Expert-Mustafa Al.png-Zoughool

Dr. Mustafa Al-Zoughool

PhD, MSc

Senior Toxicologist

Joined RSI in 2024

  • Highly respected, trusted, and recognized professional with a cross-continental career

  • Assisted in launching two Master programs in Saudi Arabia and Kuwait

  • Vice Dean Academic Affairs for 4 years in the College of Public Health at Kuwait University

Dr. Al-Zoughool has maintained a long-standing relationship with Risk Sciences International, both as a scientific collaborator and as a co-investigator on complex international projects. His work with RSI focuses on high-level public health risk modeling, mechanistic data analysis, and toxicological risk assessment of major environmental contaminants in air, soil, and water, including formaldehyde, lead, and 1,4-dioxane. His research also extends to methodological innovation and the development of evidence-based strategies for environmental and occupational health policy.

His collaborations with RSI have encompassed diverse domains, including the health effects of air pollution, derivation of points of departure for carcinogenic risk assessment, exposure-based toxicokinetic modeling, occupational asthma, disease burden estimation, and quantitative modeling of emerging infectious diseases. He is a frequent contributor to RSI’s global research initiatives, including projects on carcinogen characterization, risk prioritization under climate change, and population health scenario modeling.

Pre-RSI

Dr. Mustafa Al-Zoughool earned his MSc in Analytical Toxicology from the University of Jordan and his PhD in Toxicology from the University of Cincinnati in the United States, where his doctoral research focused on the molecular pathways of chemical-induced carcinogenesis.

He subsequently joined the International Agency for Research on Cancer (IARC) as a postdoctoral fellow, where he led a study examining the relationship between cigarette smoking and the risk of endometrial cancer. Later, at the McLaughlin Centre for Population Health Risk Assessment at the University of Ottawa, Dr. Al-Zoughool led several multidisciplinary projects spanning molecular toxicology, cancer epidemiology, mathematical modeling of prion diseases, and population health risk assessment.

His career has also included academic appointments at universities in Saudi Arabia and Kuwait, where he taught courses in biology, toxicology, environmental health, and infectious diseases, and supervised numerous graduate research projects in environmental health risk assessment. At both institutions, he played a key role in establishing new master’s programs in public health.

Presenting a poster in the same Prion2007 conference in Edinburgh, Scotland.

Mustafa Al-Zoughool at work

Publications associated with Mustafa Al-Zoughool

Health effects of radon: a review of the literature.


ABSTRACT

PURPOSE: Radon is natural radioactive noble gas that can be found in soil, water, outdoor and indoor air. Exposure to radon accounts for more that 50% of the annual effective dose of natural radioactivity. The purpose of the current review...
Publication details about Health effects of radon: a review of the literature.

Case-control study of radon and lung cancer in New Jersey.


ABSTRACT

Radon is known to cause lung cancer in humans; however, there remain uncertainties about the effects associated with residential exposures. This case-control study of residential radon and lung cancer was conducted in five counties in New Jersey and involved 561...
Publication details about Case-control study of radon and lung cancer in New Jersey.

Effect of N-glucuronidation on urinary bladder genotoxicity of 4-aminobiphenyl in male and female mice.


ABSTRACT

Urinary bladder cancer is the fourth most commonly diagnosed malignancy in men and the tenth most commonly diagnosed malignancy in women in the US. Arylamines have long been associated with bladder cancer and several studies documented that men exposed to...
Publication details about Effect of N-glucuronidation on urinary bladder genotoxicity of 4-aminobiphenyl in male and female mice.

Randomized controlled trial: effects of diet on DNA damage in heavy smokers.


ABSTRACT

We have conducted a randomized trial which investigated the ability of dietary changes (in particular diets rich in cruciferous vegetables and flavonoids), to increase urinary antimutagenicity and inhibit DNA damage in smokers. Ninety heavy smokers were recruited and randomly assigned...
Publication details about Randomized controlled trial: effects of diet on DNA damage in heavy smokers.

Exposure of mice to arsenic and/or benzo[a]pyrene does not increase the frequency of Aprt-deficient cells recovered from explanted skin of Aprt heterozygous mice.


ABSTRACT

Exposure to inorganic arsenic in drinking water is linked to cancer in humans, but the mechanism of arsenic-induced cancer is not clear. Arsenic is not a powerful point mutagen, but can cause chromosome malsegregation and mitotic recombination, two events that...
Publication details about Exposure of mice to arsenic and/or benzo[a]pyrene does not increase the frequency of Aprt-deficient cells recovered from explanted skin of Aprt heterozygous mice.

Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skin.


ABSTRACT

Exposure to inorganic arsenic in drinking water is linked to skin, lung and bladder cancer in humans. The mechanism of arsenic-induced cancer is not clear, but exposure to arsenic and polycyclic arylhydrocarbons (PAH) is more carcinogenic than exposure to either...
Publication details about Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skin.

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Outside RSI

Mustafa is an avid traveler with a strong passion for exploring new places and cultures. He has a deep appreciation for nature and enjoys spending quality time with his family, taking long hikes, jogging, fishing, and camping.

At Alhambra Palace, Granada, Spain back in October 2008

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