RSI's Franco Momoli

Franco Momoli

Vice-President Chemical and Product Safety

Joined RSI in 2019

  • Experienced epidemiologist and biostatistician

  • Adjunct Professor at the University of Ottawa, School of Epidemiology and Public Health

  • Broad experience in clinical research and environmental chemical human health risk assessment

  • Expert in evidence synthesis and quantitative bias modelling of epidemiologic studies

  • Served as a member and interim chair of the CHEO Research Ethics Board

Dr. Franco Momoli joined Risk Sciences International (RSI) in 2019 and currently serves as Vice-President, Chemical and Product Safety. In this role, he leads a multidisciplinary team of epidemiologists, risk assessors, toxicologists, and biostatisticians in conducting human health risk assessments related to environmental contaminants and consumer products. His practice group supports government agencies, regulatory bodies, and international partners in making science-informed decisions that safeguard public health.

As RSI’s lead on chemical and product safety, Dr. Momoli has guided major projects including:

  • Systematic review and robust evidence integration of epidemiologic and toxicologic data—including human, animal, and mechanistic studies—for Health Canada on the health effects of fluoride, arsenic, and asbestos, covering drinking water and inhalation exposure routes;
  • Safety assessment of residual barium impurities in a novel clinical therapeutic product, including derivation of a permissible daily exposure;
  • Development of a Bayesian Network weight-of-evidence tool for Health Canada to support hazard identification in environmental chemical risk assessments;
  • Benchmark dose modelling to derive points of departure as a first step in developing regulatory health-based values for arsenic and fluoride;
  • Mode-of-action framework analysis of mechanistic data on formaldehyde and upper respiratory tumors;
  • Numerous projects and publications for the International Manganese Institute on biomarkers of manganese exposure, including updated diagnostic recommendations for manganism;
  • Collaboration with the European Food Safety Authority (EFSA) on a problem formulation framework for risk assessment guidelines, and development of the APRIO structured question framework for designing research and risk assessment questions;
  • Support to Health Canada on a modernized, public health–driven approach to chemicals management;
  • Consulting for the Canadian Partnership Against Cancer, focusing on modernizing provincial and territorial cancer registries, including artificial intelligence applications;
  • Toxicokinetic modelling of lead at Canadian contaminated sites using the US EPA All-Ages Lead Model, Version 3; and
  • Consultations on methodologies for deriving points of departure for formaldehyde and particulate matter (PM2.5 and PM10).

At RSI, Dr. Momoli is recognized for integrating modern methodologies with real-world applicability. His dedication to methodological rigor, statistical clarity, and policy relevance has shaped RSI’s approach to chemical risk assessment and consumer product safety. In addition to his leadership at RSI, he holds an appointment as Adjunct Professor (previously Associate Professor) in the School of Epidemiology and Public Health at the University of Ottawa, bridging academic theory with regulatory application.

Pre-RSI

Dr. Momoli’s career began not in epidemiology, but in the animal sciences, where his fascination with human aging was sparked by Caleb Finch’s Longevity, Senescence, and the Genome. This early interest led him to graduate work on Alzheimer’s disease, conducting behavioural and cognitive testing on transgenic and knockout mouse models as part of his M.Sc. research at McGill University and the Douglas Hospital Research Institute.

He later transitioned into epidemiology and biostatistics, where he earned a Ph.D. at McGill University. Over the years, Dr. Momoli developed specialized expertise in semi-Bayesian models, quantitative bias modeling, and the application of advanced statistical methods to population health.

As a professor at the University of Ottawa, Dr. Momoli taught and mentored numerous graduate students, many of whom now hold influential roles in academia, public health, and research institutions. He was one of Canada’s principal scientists in the MOBI-Kids international study on non-ionizing radiation from cell phones and brain tumors in youth.

Prior to joining RSI, he spent a decade at the research institutes of The Ottawa Hospital and the Children’s Hospital of Eastern Ontario (CHEO), where he collaborated on a broad range of studies in adult and pediatric health. These included diagnostic accuracy studies, randomized controlled trials of medical and device interventions, scoping and systematic reviews of new therapeutic products, survey design, and secondary data analyses of hospital records, spanning many topics in clinical research. During this time, he also served on research ethics boards at both institutions, including as interim chair of the CHEO Research Ethics Board, and was a member of CHEO’s Policy Ethics Board—roles that deepened his perspective on ethical dimensions in clinical and epidemiological research.

As an educator and methods specialist, he often attempted to popularize modern design and analytical methods to improve the quality of evidence; he frequently joined journal clubs with trainees or physicians to discuss recently published research from a methodologic perspective, including clubs for radiologists, orthopedic surgeons, dermatologists, vascular surgeons, pediatric medical residents, and intensive care physicians.

During his time with the research institutes, Dr. Momoli was a longstanding member of the CHEO SPARK Group (Sleep-disordered Breathing in Populations of At-Risk Kids), Ottawa Brain Tumor Group, Ottawa Hospital Upper Extremity Orthopaedics Research Group, Ottawa Hospital Delirium in Palliative Settings Research Group, Ottawa Hospital Urology Research Group, Ottawa Hospital Stroke Research Group, and Ottawa Hospital Vascular Surgery Research Group. He was a member of various research teams, including Evaluation to Action (Aboriginal Child Health), 5P (Predicting Persistent Post-Concussive Problems in Paediatrics), SUNDIPS (Studies to Understand Delirium in Palliative Care Settings), MOBI-Kids Consortium (Brain Tumor Etiology in Youth), and the DDEPICT/DDACA (Determination of Death) Investigators Group.

He is an author of several book chapters on environmental health and toxicology, including Patty’s Industrial Hygiene and Toxicology, the Encyclopedia of Environmental Health, and the International Encyclopedia of Public Health. He has published over 100 articles across the breadth of epidemiologic clinical research, as well as epidemiologic and toxicologic human health risk assessments of chemicals.

Dr. Momoli, who believes teaching is a vocation, giving one of his many and regular lectures.

Case studies associated with Franco Momoli

Drinking Water Guidelines for Manganese

PROJECT DESCRIPTION

Establishing science-based drinking water guidelines for manganese requires integrating diverse regulatory approaches, emerging modeling tools, and evolving toxicological evidence. The client commissioned this project to systematically assess existing manganese drinking water guidelines and the scientific foundations upon which they are...
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EFSA Framework for Problem Formulation

PROJECT DESCRIPTION

To enhance the methodological rigour of its scientific assessments, EFSA sought to develop a standardised framework for problem formulation (PF) within its non-application scientific assessment protocols. The goal was to support the planning phase of these assessments by establishing a...
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Environmental Public Health Approach (EPHA) to Chemicals Expert Workshop

PROJECT DESCRIPTION

To advance the Government of Canada’s Chemicals Management Plan (CMP), a virtual expert workshop was planned and hosted to refine and evaluate a Canadian framework for the Environmental Public Health Approach (EPHA) to chemicals. The initiative focused on developing case...
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Communication material on lithium in drinking water and health risks

PROJECT DESCRIPTION

To support public communication around emerging drinking water concerns, RSI was engaged to develop accessible, scientifically grounded materials on lithium exposure and its potential health effects. The work focused on equipping stakeholders with clear, credible information that could inform both...
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Applying New Assessment Methods (NAMs) for Assessing Semi-Volatile Organic Compounds (SVOCs) in Indoor Residential Environments

PROJECT DESCRIPTION

Health Canada sought expert support in advancing its efforts to develop screening values for semi-volatile organic compounds (SVOCs) commonly found in residential indoor environments. Previous work on indoor air contaminants had focused on volatile organic compounds (VOCs), where screening values...
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External Peer Review of the Draft Screening Assessment Report on Selected C3-C5 Alcohols

PROJECT DESCRIPTION

To support the quality and defensibility of regulatory decision-making under the Canadian Environmental Protection Act, 1999 (CEPA), Health Canada engaged Risk Sciences International to coordinate an independent external peer review of the Draft Screening Assessment Report (DSAR) for Selected C3-C5...
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External Peer Consultation of the Inorganic – Late Biomonitoring Approach Draft Screening Assessment Report

PROJECT DESCRIPTION

To support the Chemicals Management Plan under the Canadian Environmental Protection Act (CEPA), Health Canada sought expert peer consultation for a draft screening assessment report (DSAR) evaluating 47 inorganic substances identified as priorities. The client required independent scientific and technical...
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Age-Related Cognitive Decline: Systematic Review and Meta-Analysis

PROJECT DESCRIPTION

The College of Physicians & Surgeons of Alberta (CPSA) commissioned a systematic review and meta-analysis to support evidence-informed decision-making around age-related cognitive decline among practicing physicians. The initiative was led by CPSA’s Physician Health Monitoring Program (PHMP), which sought to...
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Publications associated with Franco Momoli

Diagnosis of manganism and manganese neurotoxicity: A workshop report.


ABSTRACT

With declining exposures to manganese (Mn) in occupational settings, there is a need for more sensitive exposure assessments and clinical diagnostic criteria for manganism and Mn neurotoxicity. To address this issue, a workshop was held on November 12-13, 2020, with...
Publication details about Diagnosis of manganism and manganese neurotoxicity: A workshop report.

Long-Term Care Ownership and Operator Factors in Probable Delirium: A Population-Based Study from Ontario, Canada.


ABSTRACT

OBJECTIVES: To evaluate the association between long-term care (LTC) home ownership models and operator characteristics and the prevalence of probable delirium. DESIGN: Cross-sectional study using provincial health administrative data. SETTING AND PARTICIPANTS: All LTC residents aged 65-105 years in Ontario,...
Publication details about Long-Term Care Ownership and Operator Factors in Probable Delirium: A Population-Based Study from Ontario, Canada.

Paediatric Reference Intervals and Curves for Haemoglobin Estimated Using Direct Methods: A Systematic Review and Meta-Analysis.


ABSTRACT

INTRODUCTION: Haemoglobin is a commonly ordered laboratory test, used to assess both individual and population-level health. To interpret test results, laboratories provide reference intervals (RIs) with lower (2.5th%) and upper (97.5th%) limits according to age and sex. Reference curves (RCs)...
Publication details about Paediatric Reference Intervals and Curves for Haemoglobin Estimated Using Direct Methods: A Systematic Review and Meta-Analysis.

Systematic review of epidemiological and toxicological evidence on health effects of fluoride in drinking water.


ABSTRACT

INTRODUCTION: Fluoride is a naturally occurring substance that is also added to drinking water, dental hygiene products, and food supplements for preventing dental caries. Concerns have been raised about several other potential health risks of fluoride. OBJECTIVE: To conduct a...
Publication details about Systematic review of epidemiological and toxicological evidence on health effects of fluoride in drinking water.

Nonparticipation Selection Bias in the MOBI-Kids Study.


ABSTRACT

BACKGROUND: MOBI-Kids is a 14-country case-control study designed to investigate the potential effects of electromagnetic field exposure from mobile telecommunications devices on brain tumor risk in children and young adults conducted from 2010 to 2016. This work describes differences in...
Publication details about Nonparticipation Selection Bias in the MOBI-Kids Study.

The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Technologies and Possible Association with Brain Tumor Risk.


ABSTRACT

The rapid increase in mobile phone use in young people has generated concern about possible health effects of exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF). MOBI-Kids, a multinational case-control study, investigates the potential effects of...
Publication details about The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Technologies and Possible Association with Brain Tumor Risk.

Mental Health Service Utilization in Depressed Canadian Armed Forces Personnel.


ABSTRACT

BACKGROUND: Major depression is prevalent, impactful, and treatable in military populations, but not all depressed personnel seek professional care in a given year. Care-seeking patterns (including the use of primary vs. specialty care) and factors associated with the likelihood of...
Publication details about Mental Health Service Utilization in Depressed Canadian Armed Forces Personnel.

Mental Health Service Use in Depressed Military Personnel: A Systematic Review.


ABSTRACT

INTRODUCTION: Major depression is a leading cause of morbidity in military personnel and an important impediment to operational readiness in military organizations. Although treatment options are available, a large proportion of individuals with depression do not access mental health services....
Publication details about Mental Health Service Use in Depressed Military Personnel: A Systematic Review.

Incidence of major depression diagnoses in the Canadian Armed Forces: longitudinal analysis of clinical and health administrative data.


ABSTRACT

PURPOSE: Major depression is a leading cause of morbidity in military populations. However, due to a lack of longitudinal data, little is known about the rate at which military personnel experience the onset of new episodes of major depression. We...
Publication details about Incidence of major depression diagnoses in the Canadian Armed Forces: longitudinal analysis of clinical and health administrative data.

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RSI News associated with Franco Momoli

Aging and cognitive decline

Working with the College of Physicians and Surgeons of Alberta, Risk Sciences International conducted a wide-ranging review of aging and cognitive decline, with specific focus on aging physicians and fitness to practice.  The publication in Aging & Mental Health documents domains of cognition that decline with older age, concerns with...
News article about Aging and cognitive decline

Quinolones and risk of retinal detachment

Following previous work on the potential risk of acute liver failure associated with quinolone antibiotics, RSI investigators, Mohamed Taher, Franco Momoli, Donald Mattison and Daniel Krewski evaluated the potential risk of retinal detachment (RD) associated with these medications. Although no cases of RD were linked to quinolones in clinical trials, some...
News article about Quinolones and risk of retinal detachment

Outside RSI

Outside the office, Franco Momoli blends intellectual curiosity with physical balance and creative pursuits. A firm believer that teaching is a vocation, he remains engaged in academia not just as an adjunct professor but as a public educator, frequently lecturing on statistical modeling, risk interpretation, and the interplay between science and policy.

Franco’s love of classic literature informs his way of thinking—structured, reflective, and precise. He also finds peace on the water, often kayaking the Ottawa River or exploring local waterways. Whether alone in a kayak or in a dragon boat crew, Franco sees rhythm and balance as essential—not unlike the principles that guide his epidemiologic modeling.

He is also a devoted student and practitioner of Aikido, a martial art that emphasizes the redirection of energy, intentionality, and mutual respect—values that mirror his approach to leadership and mentorship. And when not kayaking, lecturing, or solving statistical puzzles, Franco is likely savoring good coffee, something he treats as both ritual and reward.

Whether at work or at rest, Dr. Momoli embodies the ethos of deliberate inquiry, methodical progress, and quiet excellence—a rare blend of scientific rigor and humanistic sensibility.

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