RSI Expert-Natalia Shilnikova

Dr. Natalia (Natasha) Shilnikova

MD, PhD

Senior Health Risk Analyst

Joined RSI in 2011

  • 20 years studying late health effects of radiation in workers of the Russian nuclear complex Mayak

  • Member of IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2000)

Dr. Natalia (Natasha) Shilnikova is a Senior Health Risk Analyst at Risk Sciences International (RSI), where she has contributed since 2011 to some of the organization’s most analytically demanding and policy-relevant projects. With a background in medicine and a PhD in medical sciences, Dr. Shilnikova specializes in the synthesis of epidemiological evidence, human health risk assessment, toxicology, and critical literature reviews—applying her expertise across a spectrum of regulatory and public health priorities.

At RSI, she has served as a lead or contributing analyst on projects for Health Canada, the Canadian Partnership Against Cancer, the College of Physicians and Surgeons of Alberta, the Workplace Safety Insurance Board, and numerous international clients. Her work has included:

  • Synthesis of scientific information on methodological approaches for derivation of health-based air quality objectives for particulate matter;
  • Evidence syntheses on cannabis and cancer risk, abnormal call rates in breast cancer screening, and cognitive screening of older physicians;
  • Critical reviews of toxicological profiles for priority substances under Canada’s Domestic Substances List (DSL);
  • Hazard assessments of metals such as aluminum and manganese, including international work on biomarkers of exposure for the International Manganese Institute;
  • Support for ethical frameworks in risk assessment through commissioned background papers and workshops.

Dr. Shilnikova has also contributed to RSI’s internal and client-facing report development, serving as both content expert and co-author on over a dozen high-impact technical documents and scientific literature reviews between 2012 and 2025. Her capacity to navigate between population-level epidemiology and molecular toxicology gives her work rare depth—particularly when distilling uncertainty into actionable risk decisions.

Pre-RSI

Dr. Shilnikova began her scientific career in Russia, earning her MD from Perm State Medical Institute (now Perm State Medical Academy), followed by a PhD in Medical Sciences from the State Research Center Institute of Biophysics, part of the Federal Medico-Biological Agency (FMBA) of the Russian Federation.

She spent many years as a researcher at the Southern Ural Biophysics Institute in Ozyorsk (Chelyabinsk region), where she conducted epidemiological analyses on mortality and cancer incidence in workers at the Mayak nuclear facility—one of Russia’s nuclear complexes—and among populations residing near the plant. Her research contributed to long-term health studies funded by the U.S. National Cancer Institute and the U.S. Department of Energy, and resulted in landmark publications in radiation epidemiology and low-dose health effects.

In 2000, Dr. Shilnikova served as a member of IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (Lyon, June 14-21, 2000). Together with Dr. Nina Koshurnikova, she prepared section 2.4.3 “Plutonium. Russian Federation” for volume 78 “Ionizing Radiation, Part 2: Some Internally Deposited Radionuclides” of the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC Press, Lyon, France, 2001.

After moving to Canada in 2007, she joined the McLaughlin Centre for Population Health Risk Assessment at the University of Ottawa, where she worked on projects involving the health impacts of chemical, physical, and biological agents, setting the stage for her transition to RSI in 2011.

Her body of academic work includes extensive contributions to peer-reviewed literature on topics such as:

  • Radiation carcinogenesis and cardiovascular disease in exposed occupational cohorts;
  • Hormesis and low-dose risk;
  • Risk management for transmissible spongiform encephalopathies (e.g., BSE and vCJD);
  • Systematic reviews of talc and ovarian cancer, and other agent–disease associations.

Her unique training—combining clinical, regulatory, and population health lenses—equips her to work at the interface of science and policy, with particular strength in complex exposure-disease modeling and structured expert elicitation.

Natasha Shilnikova at the international expert panel workshop organized by RSI and the International Manganese Institute (IMnI)

Case studies associated with Natalia (Natasha) Shilnikova

Systematic Review of Artificial Sweeteners and Health Risks

PROJECT DESCRIPTION

A comprehensive systematic review was undertaken to assess experimental evidence regarding the potential health risks associated with artificial sweeteners, specifically focusing on cancer and pre-term delivery. The client sought a rigorous analysis of both in vivo and in vitro experimental...
Read More about Systematic Review of Artificial Sweeteners and Health Risks

Publications associated with Natalia (Natasha) Shilnikova

Lung cancer mortality among male nuclear workers of the Mayak facilities in the former Soviet Union.


ABSTRACT

An analysis of lung cancer mortality in a cohort of 1,669 Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. Particular emphasis...
Publication details about Lung cancer mortality among male nuclear workers of the Mayak facilities in the former Soviet Union.

Liver cancers in Mayak workers.


ABSTRACT

Liver cancer mortality risks were evaluated in 11,000 workers who started working at the "Mayak" Production Association in 1948-1958 and who were exposed to both internally deposited plutonium and external gamma radiation. Comparisons with Russian liver cancer incidence rates indicate...
Publication details about Liver cancers in Mayak workers.

Bone cancers in Mayak workers.


ABSTRACT

Bone cancer mortality risks were evaluated in 11,000 workers who started working at the "Mayak" Production Association in 1948-1958 and who were exposed to both internally deposited plutonium and external gamma radiation. Comparisons with Russian and U.S. general population rates...
Publication details about Bone cancers in Mayak workers.

Characteristics of the cohort of workers at the Mayak nuclear complex.


ABSTRACT

At Branch No. 1 of the Russian State Research Center "Biophysics Institute", a registry has been created of workers at the "Mayak" Production Association, the first nuclear complex in Russia. This registry includes 18,830 persons hired at Mayak's nuclear reactors...
Publication details about Characteristics of the cohort of workers at the Mayak nuclear complex.

Lung cancer risk due to exposure to incorporated plutonium.


ABSTRACT

An epidemiological study has been carried out among 1,479 male workers who started working at the "Mayak" Production Association in 1948-1958 and were exposed to external gamma radiation and plutonium aerosols. Lung cancer mortality for the follow-up period 1948-1993 has...
Publication details about Lung cancer risk due to exposure to incorporated plutonium.

Mortality among workers with chronic radiation sickness.


ABSTRACT

This study is based on a registry containing medical and dosimetric data of the employees who began working at different plants of the Mayak nuclear complex between 1948 and 1958 who developed chronic radiation sickness. Mayak is the first nuclear...
Publication details about Mortality among workers with chronic radiation sickness.

Mortality among personnel who worked at the Mayak complex in the first years of its operation.


ABSTRACT

Epidemiological studies revealed increased cancer mortality among persons who began working at the Mayak complex during the period 1948-1958. Estimation of cancer risk was carried out for the sites of cancer that showed increased mortality and dependence on dose of...
Publication details about Mortality among personnel who worked at the Mayak complex in the first years of its operation.

Verification of occupational doses at the first nuclear plant in the former Soviet Union.


ABSTRACT

Mean annual occupational exposures are reported for radiation workers at the first Russian industrial nuclear facility 'Mayak', South Ural region, for the period 1948-1988. The underlying individual doses originate from the register of the in-plant radiation safety department and are...
Publication details about Verification of occupational doses at the first nuclear plant in the former Soviet Union.

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RSI News associated with Natalia (Natasha) Shilnikova

Aging and cognitive decline

Working with the College of Physicians and Surgeons of Alberta, Risk Sciences International conducted a wide-ranging review of aging and cognitive decline, with specific focus on aging physicians and fitness to practice.  The publication in Aging & Mental Health documents domains of cognition that decline with older age, concerns with...
News article about Aging and cognitive decline

Outside RSI

Outside of her professional work, Dr. Shilnikova maintains a quiet profile, though her intellectual curiosity and cultural range are evident in her scholarly pursuits and scientific collaborations. Known to her colleagues as deeply thoughtful, rigorous, and committed to public health, she brings not only a wealth of experience but a transnational perspective informed by careers on two continents.

She regularly contributes to international panels and expert working groups, including RSI’s long-standing collaborations with academic and regulatory bodies across Canada, Europe, and the United States. Her publications and reports are widely cited in the fields of epidemiology, toxicology, environmental health, and evidence synthesis.

Though details of her personal interests are not publicly shared, Dr. Shilnikova’s legacy of scientific contribution, intellectual integrity, and commitment to evidence-based decision-making is well established. At RSI, she continues to exemplify the best of applied public health science: disciplined, humane, and always grounded in the pursuit of clarity in uncertainty.

Direct contact with Natalia (Natasha) Shilnikova

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