RSI Expert-Natalia Shilnikova

Natalia (Natasha) Shilnikova

Senior Health Risk Analyst

Joined RSI in 2011

  • 20 years studying late health effects of radiation in workers of the Russian nuclear complex Mayak

  • Member of IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2000)

Dr. Natalia (Natasha) Shilnikova is a Senior Health Risk Analyst at Risk Sciences International (RSI), where she has contributed since 2011 to some of the organization’s most analytically demanding and policy-relevant projects. With a background in medicine and a PhD in medical sciences, Dr. Shilnikova specializes in the synthesis of epidemiological evidence, human health risk assessment, toxicology, and critical literature reviews—applying her expertise across a spectrum of regulatory and public health priorities.

At RSI, she has served as a lead or contributing analyst on projects for Health Canada, the Canadian Partnership Against Cancer, the College of Physicians and Surgeons of Alberta, the Workplace Safety Insurance Board, and numerous international clients. Her work has included:

  • Synthesis of scientific information on methodological approaches for derivation of health-based air quality objectives for particulate matter;
  • Evidence syntheses on cannabis and cancer risk, abnormal call rates in breast cancer screening, and cognitive screening of older physicians;
  • Critical reviews of toxicological profiles for priority substances under Canada’s Domestic Substances List (DSL);
  • Hazard assessments of metals such as aluminum and manganese, including international work on biomarkers of exposure for the International Manganese Institute;
  • Support for ethical frameworks in risk assessment through commissioned background papers and workshops.

Dr. Shilnikova has also contributed to RSI’s internal and client-facing report development, serving as both content expert and co-author on over a dozen high-impact technical documents and scientific literature reviews between 2012 and 2025. Her capacity to navigate between population-level epidemiology and molecular toxicology gives her work rare depth—particularly when distilling uncertainty into actionable risk decisions.

Pre-RSI

Dr. Shilnikova began her scientific career in Russia, earning her MD from Perm State Medical Institute (now Perm State Medical Academy), followed by a PhD in Medical Sciences from the State Research Center Institute of Biophysics, part of the Federal Medico-Biological Agency (FMBA) of the Russian Federation.

She spent many years as a researcher at the Southern Ural Biophysics Institute in Ozyorsk (Chelyabinsk region), where she conducted epidemiological analyses on mortality and cancer incidence in workers at the Mayak nuclear facility—one of Russia’s nuclear complexes—and among populations residing near the plant. Her research contributed to long-term health studies funded by the U.S. National Cancer Institute and the U.S. Department of Energy, and resulted in landmark publications in radiation epidemiology and low-dose health effects.

In 2000, Dr. Shilnikova served as a member of IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (Lyon, June 14-21, 2000). Together with Dr. Nina Koshurnikova, she prepared section 2.4.3 “Plutonium. Russian Federation” for volume 78 “Ionizing Radiation, Part 2: Some Internally Deposited Radionuclides” of the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. IARC Press, Lyon, France, 2001.

After moving to Canada in 2007, she joined the McLaughlin Centre for Population Health Risk Assessment at the University of Ottawa, where she worked on projects involving the health impacts of chemical, physical, and biological agents, setting the stage for her transition to RSI in 2011.

Her body of academic work includes extensive contributions to peer-reviewed literature on topics such as:

  • Radiation carcinogenesis and cardiovascular disease in exposed occupational cohorts;
  • Hormesis and low-dose risk;
  • Risk management for transmissible spongiform encephalopathies (e.g., BSE and vCJD);
  • Systematic reviews of talc and ovarian cancer, and other agent–disease associations.

Her unique training—combining clinical, regulatory, and population health lenses—equips her to work at the interface of science and policy, with particular strength in complex exposure-disease modeling and structured expert elicitation.

Natasha Shilnikova at the international expert panel workshop organized by RSI and the International Manganese Institute (IMnI)

Case studies associated with Natalia (Natasha) Shilnikova

Systematic Review of Artificial Sweeteners and Health Risks

PROJECT DESCRIPTION

A comprehensive systematic review was undertaken to assess experimental evidence regarding the potential health risks associated with artificial sweeteners, specifically focusing on cancer and pre-term delivery. The client sought a rigorous analysis of both in vivo and in vitro experimental...
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Publications associated with Natalia (Natasha) Shilnikova

Diagnosis of manganism and manganese neurotoxicity: A workshop report.


ABSTRACT

With declining exposures to manganese (Mn) in occupational settings, there is a need for more sensitive exposure assessments and clinical diagnostic criteria for manganism and Mn neurotoxicity. To address this issue, a workshop was held on November 12-13, 2020, with...
Publication details about Diagnosis of manganism and manganese neurotoxicity: A workshop report.

Should we screen aging physicians for cognitive decline?


ABSTRACT

OBJECTIVES: To synthesize evidence relevant for informed decisions concerning cognitive testing of older physicians. METHODS: Relevant literature was systematically searched in Medline, EMBASE, PsycInfo, and ERIC, with key findings abstracted and synthesized. RESULTS: Cognitive abilities of physicians may decline in...
Publication details about Should we screen aging physicians for cognitive decline?

Review of non-invasive biomarkers as a tool for exposure characterization in human health risk assessments.


ABSTRACT

Blood and urine are historically the most frequent matrices used for measuring chemical levels in human biomonitoring studies. As biomonitoring programs are refreshed, consideration of specific priority substances and specific population targets provide opportunities for inclusion of alternative non- or...
Publication details about Review of non-invasive biomarkers as a tool for exposure characterization in human health risk assessments.

Biomarkers for occupational manganese exposure.


ABSTRACT

Long-term inhalation exposure to manganese (Mn) metal or its inorganic compounds can result in manganism or subclinical neurofunctional deficits. Studies have described affected workers in Mn dioxide mining, Mn-containing ore crushing and milling facilities, manufacturing of dry-cell batteries, Mn steel...
Publication details about Biomarkers for occupational manganese exposure.

Magnetic resonance imaging T1 indices of the brain as biomarkers of inhaled manganese exposure.


ABSTRACT

Excessive exposure to manganese (Mn) is linked to its accumulation in the brain and adverse neurological effects. Paramagnetic properties of Mn allow the use of magnetic resonance imaging (MRI) techniques to identify it in biological tissues. A critical review was...
Publication details about Magnetic resonance imaging T1 indices of the brain as biomarkers of inhaled manganese exposure.

The REACH registration process: A case study of metallic aluminium, aluminium oxide and aluminium hydroxide.


ABSTRACT

The European Union's REACH Regulation requires determination of potential health and environmental effects of chemicals in commerce. The present case study examines the application of REACH guidance for health hazard assessments of three high production volume (HPV) aluminium (Al) substances:...
Publication details about The REACH registration process: A case study of metallic aluminium, aluminium oxide and aluminium hydroxide.

Biomarkers of environmental manganese exposure.


ABSTRACT

We conducted a critical review on biomarkers of environmental manganese (Mn) exposure to answer the following questions: 1) are there reliable biomarkers of internal Mn exposure (Mn in biological matrices) associated with external metrics of Mn exposure (Mn in environmental...
Publication details about Biomarkers of environmental manganese exposure.

Malignant neoformations of the hematopoietic and lymphoid tissues in the personnel of the 1st plant of atomic industry.


ABSTRACT

Rates of mortality from hemopoietic and lymphoid malignancies for 1948-1987 were studied in male staff of industrial atomic reactors and radiochemical industry for irradiated uranium processing versus dose of external gamma radiation. An increase in mortality due to radiation--induced acute...
Publication details about Malignant neoformations of the hematopoietic and lymphoid tissues in the personnel of the 1st plant of atomic industry.

Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data.


ABSTRACT

INTRODUCTION: Lithium salts have numerous industrial uses and are also used in the treatment of bipolar disorders. The main source of lithium exposure to the general population is drinking water and foods. Lithium is nephrotoxic at higher doses. Thus, oral...
Publication details about Derivation of whole blood biomonitoring equivalents for lithium for the interpretation of biomonitoring data.

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RSI News associated with Natalia (Natasha) Shilnikova

Aging and cognitive decline

Working with the College of Physicians and Surgeons of Alberta, Risk Sciences International conducted a wide-ranging review of aging and cognitive decline, with specific focus on aging physicians and fitness to practice.  The publication in Aging & Mental Health documents domains of cognition that decline with older age, concerns with...
News article about Aging and cognitive decline

Outside RSI

Outside of her professional work, Dr. Shilnikova maintains a quiet profile, though her intellectual curiosity and cultural range are evident in her scholarly pursuits and scientific collaborations. Known to her colleagues as deeply thoughtful, rigorous, and committed to public health, she brings not only a wealth of experience but a transnational perspective informed by careers on two continents.

She regularly contributes to international panels and expert working groups, including RSI’s long-standing collaborations with academic and regulatory bodies across Canada, Europe, and the United States. Her publications and reports are widely cited in the fields of epidemiology, toxicology, environmental health, and evidence synthesis.

Though details of her personal interests are not publicly shared, Dr. Shilnikova’s legacy of scientific contribution, intellectual integrity, and commitment to evidence-based decision-making is well established. At RSI, she continues to exemplify the best of applied public health science: disciplined, humane, and always grounded in the pursuit of clarity in uncertainty.

Direct contact with Natalia (Natasha) Shilnikova

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