Case Studies

The case studies listed here are for demonstration purposes exclusively. They are neither intended as references nor as validation by RSI clients. These case studies are a sample of the work done by RSI or directly led by its staff prior to joining RSI. They are intended as an illustration of the type of work that current RSI staff are able to deliver.

Methodology for Developing Risk Significance Insights

The project centered on supporting the development of a methodology that could eventually be implemented as an Artificial Intelligence (AI) or Machine Learning (ML) process. The objective was to help formalize and potentially automate how professional judgment is applied when...
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Developing a Risk-Based Compliance Framework for Digital Service Delivery

The Financial Consumer Agency of Canada (FCAC) engaged Risk Sciences International to provide strategic advisory services aimed at enhancing its regulatory compliance model through risk-based methodologies. FCAC’s objective was to explore new approaches that would integrate digital tools and data-driven...
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Analysis in Support of Risk-Based Decision-Making for the Alberta Safety Codes Council

An independent regulatory organization responsible for oversight of Alberta’s safety codes system sought to strengthen its capacity for risk-based decision-making. The organization aimed to ensure that regulatory actions—particularly in the area of petroleum storage tanks—were guided by clear, evidence-based prioritization...
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Building an international alliance and campaign

UN-Habitat sought to establish a new global platform to bring coherence to international dialogue on sustainable urbanization. At the outset, this initiative had no name, no identity, and no governing structure, only the recognition that cities faced pressing challenges requiring...
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Risk-based decision making framework

The Alliance of Blood Operators (ABO) sought to move its members toward a consistent, transparent approach to risk-based decision-making. Having worked through the development of a framework, the organization now wanted formal adoption, external validation, and practical application to real-world...
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Pickering Nuclear Facility Re‑licensing

The client sought support to finalize a Commission Member Document (CMD) for the re‑licensing of a nuclear facility. Recognizing the complexity and sensitivity of reactor re‑licensing, they requested assistance in crafting communication materials that were both technically comprehensive and accessible...
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International newspaper rethink

The International Herald Tribune (IHT) sought guidance at a time of profound change in the media landscape. With the World Wide Web emerging and competition intensifying from global and regional editions of established outlets such as The Economist, The Wall...
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Characterizing uncertainty in MAF values estimated using the KEMI MAF

The client sought to improve understanding of uncertainties surrounding the application of mixture assessment factors (MAFs) for aquatic receptors, specifically those estimated using the KEMI methodology. While the KEMI MAF approach is considered technically robust, its assumptions—particularly about chemical-specific controls,...
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Applying New Assessment Methods (NAMs) for Assessing Semi-Volatile Organic Compounds (SVOCs) in Indoor Residential Environments

Health Canada sought expert support in advancing its efforts to develop screening values for semi-volatile organic compounds (SVOCs) commonly found in residential indoor environments. Previous work on indoor air contaminants had focused on volatile organic compounds (VOCs), where screening values...
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EFSA Framework for Problem Formulation

To enhance the methodological rigour of its scientific assessments, EFSA sought to develop a standardised framework for problem formulation (PF) within its non-application scientific assessment protocols. The goal was to support the planning phase of these assessments by establishing a...
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Assessing the Impact of Interstudy Variation in LOAELs on Findings of Low-Dose Additivity in In Vivo Studies of Mixtures

Demonstrating the safe use of chemical mixtures remains a critical challenge in toxicological science. In recent years, studies have suggested that chemicals can exhibit dose additivity—causing a combined effect—even when each chemical individually is below its effect threshold. This project...
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Update of WHO Guidance on Food Defense

To support international efforts in mitigating deliberate threats to the food system, the World Health Organization commissioned an update to its earlier guidance titled Terrorist Threats to Food. The revision aimed to broaden the original scope by addressing not only...
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Contraceptive recall review

Health Canada requested an external review following significant public criticism of its handling of a pharmaceutical recall. The case involved a contraceptive drug that was withdrawn due to packaging errors, and the department faced questions about whether it had acted...
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Expansion of the Stochastic Health Canada Quantitative Microbial Risk Assessment Tool

Health Canada sought to enhance its Quantitative Microbial Risk Assessment (QMRA) tool, originally developed over 15 years ago for stakeholders responsible for drinking water systems. With advancements in probabilistic modeling and microbial risk assessment, the client required updates to reflect...
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Communication material on lithium in drinking water and health risks

To support public communication around emerging drinking water concerns, RSI was engaged to develop accessible, scientifically grounded materials on lithium exposure and its potential health effects. The work focused on equipping stakeholders with clear, credible information that could inform both...
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Food safety risk analysis tools

The World Health Organization and the Food and Agriculture Organization of the United Nations asked RSI to develop a suite of online tools to support food regulators and the food industry in applying risk-based approaches to food safety. These organizations...
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Measuring impact of zoonotic animal diseases in Canada

The Canadian Food Inspection Agency sought RSI’s support in exploring how human health impacts from zoonotic diseases could be compared consistently with other public health risks. Traditionally, animal disease control decisions relied on veterinary and economic measures, but there was...
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Airport traffic flow and signage review

An international airport authority sought a comprehensive assessment of passenger and vehicle traffic flow after receiving complaints of confusion and safety concerns. Reports indicated that passengers were struggling to interpret signage, often stopping too long to process graphics, which caused...
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Drinking Water Guidelines for Manganese

Establishing science-based drinking water guidelines for manganese requires integrating diverse regulatory approaches, emerging modeling tools, and evolving toxicological evidence. The client commissioned this project to systematically assess existing manganese drinking water guidelines and the scientific foundations upon which they are...
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Development of a National Food Safety Information System and Risk Assessment Capacity in Vietnam

Authorities in Vietnam sought targeted expertise to strengthen the country’s ability to detect, assess, and respond to food safety threats. This initiative had two linked objectives: building a comprehensive, transparent, and reliable national food safety information system, and enhancing risk...
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Wildfire and residential smoke risk communication

Government authorities faced recurring challenges in communicating health risks from smoke caused by both wildfires and residential burning. While these events were becoming more frequent and more severe, the public health messages often failed to resonate with affected communities or...
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Validation and Optimization of the Computational Tool for the Microbial Risk Assessment Framework (MRAF)

To support more consistent and quantitative assessments of new micro-organisms under the Canadian Environmental Protection Act, Health Canada's New Substances Program (NSP) sought to refine the tools and processes within its Microbial Risk Assessment Framework (MRAF). The NSP had previously...
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Environmental Public Health Approach (EPHA) to Chemicals Expert Workshop

To advance the Government of Canada’s Chemicals Management Plan (CMP), a virtual expert workshop was planned and hosted to refine and evaluate a Canadian framework for the Environmental Public Health Approach (EPHA) to chemicals. The initiative focused on developing case...
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Institutional & communications assessment

In the mid-1990s the International Organization for Migration (IOM) faced one of the most pivotal moments in its history. Though it counted 76 member states, it remained outside the United Nations system, and its work was increasingly perceived to overlap...
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