A Risk Sciences International Case Study

Expansion of the Stochastic Health Canada Quantitative Microbial Risk Assessment Tool

Drinking water

Client: Health Canada

Listing of the client in no way affirms the client's support, sponsorship, or validation in any form of Risk Sciences International or the RSI staff member(s) who conducted this project during their stay with RSI or prior to joining the company. This case study is displayed for informative purposes only to demonstrate the capacity of RSI staff members. This case study reveals no proprietary information or information deemed sensitive.

Project description:

Expansion of the Stochastic Health Canada Quantitative Microbial Risk Assessment Tool

Health Canada sought to enhance its Quantitative Microbial Risk Assessment (QMRA) tool, originally developed over 15 years ago for stakeholders responsible for drinking water systems. With advancements in probabilistic modeling and microbial risk assessment, the client required updates to reflect current scientific standards and practices. Specifically, the project aimed to incorporate a "reverse QMRA" capability, allowing users to back-calculate from acceptable risk thresholds to necessary treatment interventions or source water quality targets.

To support this expansion, the project began with a focused review of how reverse QMRA methods are currently used in microbial risk modeling. Building on those insights, RSI developed new analytical components that allow the tool to work backward from health risk thresholds to identify required treatment levels or acceptable source water concentrations. This involved writing new core code and refining the interface to accommodate added flexibility and usability for different analytical scenarios.

The updated tool allows stakeholders to explore what levels of treatment are necessary to meet tolerable health risk thresholds under various source water conditions. This capability supports informed decision-making by facility operators working toward compliance with Health Canada’s drinking water guidelines. RSI was also responsible for testing the tool with feedback from Health Canada, updating technical documentation, and delivering both a summary presentation and a draft publication outlining the expanded methodology. The project was designed to result in an open-access, user-friendly application suitable for broad public use.

Start: 2024

End: 2024

Experts related to this case study

Emma Hartnett

Vice-President Risk Modelling and Simulation

Dr. Emma Hartnett is Vice-President, Risk Modelling and Simulation at Risk Sciences International (RSI), where she has been a foundational member since its inception in 2006. A globally recognized authority in quantitative risk assessment (QRA), she specializes in developing risk...
Read More about Emma Hartnett

Margaret Wilson

Senior Risk Analyst

Margaret Wilson is a Senior Risk Analyst at Risk Sciences International (RSI), where she has been a foundational member since the company’s inception in 2006. Drawing on a rare combination of scientific breadth and analytical precision, Margaret has supported and...
Read More about Margaret Wilson

Michael G. Tyshenko

Senior Health Risk Analyst

Dr. Michael G. Tyshenko is a Senior Health Risk Analyst at Risk Sciences International (RSI), where he has contributed since 2018 to some of the organization’s most complex and cross-cutting public health risk projects. As RSI’s lead on chemical peer...
Read More about Michael G. Tyshenko

More RSI Case Studies

RSI presents a very small selection of case studies to highlight some of its key work.

Institutional & communications assessment

In the mid-1990s the International Organization for Migration (IOM) faced one of the most pivotal moments in its history. Though it counted 76 member states, it remained outside the United Nations system, and its work was increasingly perceived to overlap...
Read More about Institutional & communications assessment

Characterizing uncertainty in MAF values estimated using the KEMI MAF

The client sought to improve understanding of uncertainties surrounding the application of mixture assessment factors (MAFs) for aquatic receptors, specifically those estimated using the KEMI methodology. While the KEMI MAF approach is considered technically robust, its assumptions—particularly about chemical-specific controls,...
Read More about Characterizing uncertainty in MAF values estimated using the KEMI MAF

Methodology for Developing Risk Significance Insights

The project centered on supporting the development of a methodology that could eventually be implemented as an Artificial Intelligence (AI) or Machine Learning (ML) process. The objective was to help formalize and potentially automate how professional judgment is applied when...
Read More about Methodology for Developing Risk Significance Insights

Risk-Based Optimization of Enforcement Activities

A federal agency required scientific support to enhance the effectiveness of its environmental enforcement activities. This involved identifying and analyzing the risk factors—both environmental and human health-related—that contribute to the likelihood and impact of regulatory offences. The objective was to...
Read More about Risk-Based Optimization of Enforcement Activities

Assessing the Impact of Interstudy Variation in LOAELs on Findings of Low-Dose Additivity in In Vivo Studies of Mixtures

Demonstrating the safe use of chemical mixtures remains a critical challenge in toxicological science. In recent years, studies have suggested that chemicals can exhibit dose additivity—causing a combined effect—even when each chemical individually is below its effect threshold. This project...
Read More about Assessing the Impact of Interstudy Variation in LOAELs on Findings of Low-Dose Additivity in In Vivo Studies of Mixtures

Risk Model Framework for Foodborne Campylobacteriosis via Poultry Meat Pathway

To support national public health goals, RSI was tasked with developing a quantitative microbiological risk assessment (QMRA) model to estimate the human health risks associated with the consumption of chicken in New Zealand. The core objective was to quantify the...
Read More about Risk Model Framework for Foodborne Campylobacteriosis via Poultry Meat Pathway

Wildfire and residential smoke risk communication

Government authorities faced recurring challenges in communicating health risks from smoke caused by both wildfires and residential burning. While these events were becoming more frequent and more severe, the public health messages often failed to resonate with affected communities or...
Read More about Wildfire and residential smoke risk communication

Evaluation of Drug Recall Communication and Risk Determination Processes

In response to public and ministerial concerns about the timeliness and adequacy of information shared during a major prescription drug recall, Health Canada commissioned an independent review to assess its response to the event. The situation involved a recall of...
Read More about Evaluation of Drug Recall Communication and Risk Determination Processes

Risk-based decision making framework

The Alliance of Blood Operators (ABO) sought to move its members toward a consistent, transparent approach to risk-based decision-making. Having worked through the development of a framework, the organization now wanted formal adoption, external validation, and practical application to real-world...
Read More about Risk-based decision making framework

Analysis in Support of Risk-Based Decision-Making for the Alberta Safety Codes Council

An independent regulatory organization responsible for oversight of Alberta’s safety codes system sought to strengthen its capacity for risk-based decision-making. The organization aimed to ensure that regulatory actions—particularly in the area of petroleum storage tanks—were guided by clear, evidence-based prioritization...
Read More about Analysis in Support of Risk-Based Decision-Making for the Alberta Safety Codes Council

Communication material on lithium in drinking water and health risks

To support public communication around emerging drinking water concerns, RSI was engaged to develop accessible, scientifically grounded materials on lithium exposure and its potential health effects. The work focused on equipping stakeholders with clear, credible information that could inform both...
Read More about Communication material on lithium in drinking water and health risks

Finalization of Risk Assessment on Secure Opioid Dispensing Devices

To support decision-making around modifications to opioid agonist treatment delivery, a detailed risk assessment was requested to evaluate the integration of secure dispensing devices for direct patient access to hydromorphone. Building on a previously conducted preliminary assessment, the work required...
Read More about Finalization of Risk Assessment on Secure Opioid Dispensing Devices

Risk-Based Decision-Making (RBDM) Support for Plasma Supply / Sufficiency

Facing renewed challenges in securing a reliable domestic plasma supply, Canadian Blood Services sought support to apply a Risk-Based Decision-Making (RBDM) framework. The objective was to assess the value and implications of expanding domestic plasma collection and processing capacity in...
Read More about Risk-Based Decision-Making (RBDM) Support for Plasma Supply / Sufficiency

Development of a National Food Safety Information System and Risk Assessment Capacity in Vietnam

Authorities in Vietnam sought targeted expertise to strengthen the country’s ability to detect, assess, and respond to food safety threats. This initiative had two linked objectives: building a comprehensive, transparent, and reliable national food safety information system, and enhancing risk...
Read More about Development of a National Food Safety Information System and Risk Assessment Capacity in Vietnam

Age-Related Cognitive Decline: Systematic Review and Meta-Analysis

The College of Physicians & Surgeons of Alberta (CPSA) commissioned a systematic review and meta-analysis to support evidence-informed decision-making around age-related cognitive decline among practicing physicians. The initiative was led by CPSA’s Physician Health Monitoring Program (PHMP), which sought to...
Read More about Age-Related Cognitive Decline: Systematic Review and Meta-Analysis

Pickering Nuclear Facility Re‑licensing

The client sought support to finalize a Commission Member Document (CMD) for the re‑licensing of a nuclear facility. Recognizing the complexity and sensitivity of reactor re‑licensing, they requested assistance in crafting communication materials that were both technically comprehensive and accessible...
Read More about Pickering Nuclear Facility Re‑licensing

Food safety risk analysis tools

The World Health Organization and the Food and Agriculture Organization of the United Nations asked RSI to develop a suite of online tools to support food regulators and the food industry in applying risk-based approaches to food safety. These organizations...
Read More about Food safety risk analysis tools

Validation and Optimization of the Computational Tool for the Microbial Risk Assessment Framework (MRAF)

To support more consistent and quantitative assessments of new micro-organisms under the Canadian Environmental Protection Act, Health Canada's New Substances Program (NSP) sought to refine the tools and processes within its Microbial Risk Assessment Framework (MRAF). The NSP had previously...
Read More about Validation and Optimization of the Computational Tool for the Microbial Risk Assessment Framework (MRAF)