Adverse effects of drugs among the elderly should be given special attention when considering a pharmacological intervention.
Two recent papers using large electronic health records have explored the impact of drugs with anticholinergic properties.
The first, “Associations between Anticholinergic Burden and Adverse Health Outcomes in Parkinson Disease” view here used a HealthFacts database (Cerner Corporation, Kansas City, Missouri, USA) composed of 16,302 patients with Parkinson disease.
The second “Anticholinergic drugs and risk of dementia: case-control study” view here utilized 14,453 patients with dementia and 86,403 controls from the UK Clinical Practice Research Datalink.
Both studies observed a robust relationship between the use of drugs with anticholinergic properties and adverse consequences, including dementia, increased risks of visit to emergency departments and risk of fracture. Both studies demonstrate the importance of large electronic health record systems in understanding adverse drug events.
Posted in RSI News
More RSI News
Principles of risk decision-making
RSI investigators propose fundamental principles of risk decision-making, and explore their application in a range of real-world risk decision-making contexts. These ten principles will provide valuable guidance on addressing current and future risk issues facing civil societies worldwide.
Read News ItemRisk of Myocarditis and Pericarditis
Using data from the US Centers for Disease Control (CDC) Vaccine Adverse Event Reporting System, RSI investigators collaborated on a study showing increased risks of…
Read News ItemQuinolones and risk of retinal detachment
Following previous work on the potential risk of acute liver failure associated with quinolone antibiotics, RSI investigators, Mohamed Taher, Franco Momoli, Donald Mattison and Daniel…
Read News ItemIAI climate change report
The International Aluminium Institute (IAI) recently commissioned Climate Risk Institute (CRI) and Risk Sciences International (RSI) to produce a series of informational tools evaluating and…
Read News Item