Risks of anticholinergic drugs

Adverse effects of drugs among the elderly should be given special attention when considering a pharmacological intervention.

Two recent papers using large electronic health records have explored the impact of drugs with anticholinergic properties.

The first, “Associations between Anticholinergic Burden and Adverse Health Outcomes in Parkinson Disease” view here used a HealthFacts database (Cerner Corporation, Kansas City, Missouri, USA) composed of 16,302 patients with Parkinson disease.

The second “Anticholinergic drugs and risk of dementia: case-control study” view here utilized 14,453 patients with dementia and 86,403 controls from the UK Clinical Practice Research Datalink.

Both studies observed a robust relationship between the use of drugs with anticholinergic properties and adverse consequences, including dementia, increased risks of visit to emergency departments and risk of fracture.  Both studies demonstrate the importance of large electronic health record systems in understanding adverse drug events.

Posted in

More RSI News

Quinolones and ALF risk

June 30, 2021
Risk Sciences International 1

Quinolones, a popular and powerful anti-biotic with broad coverage and reasonable safety, was concerned to be associated with acute liver failure (ALF). A study published…

Read News Item

US FDA FAERS and quinolones

June 22, 2021
RSI logo in white

Some case reports on Quinolones, a potent and globally popular group of antibiotics that are used to treat a wide range of infections, have raised…

Read News Item

Advancing Toxicity Testing webinar

May 25, 2021
Daniel Krewski at the CAAT Webinar

The Center for Alternatives to Animal Testing and the Animal-Free Safety Assessment recently held their annual meeting on advancing toxicity testing in the 21st century…

Read News Item

USC appoints Dr. Mattison distinguished professor

March 16, 2021
USC Arnold School of Public Health

Dr. Donald Mattison, RSI’s Senior Vice-President and Chief Medical Officer, has accepted an appointment as a University of South Carolina Health Sciences Distinguished Professor in the in…

Read News Item