Adverse effects of drugs among the elderly should be given special attention when considering a pharmacological intervention.
Two recent papers using large electronic health records have explored the impact of drugs with anticholinergic properties.
The first, “Associations between Anticholinergic Burden and Adverse Health Outcomes in Parkinson Disease” view here used a HealthFacts database (Cerner Corporation, Kansas City, Missouri, USA) composed of 16,302 patients with Parkinson disease.
The second “Anticholinergic drugs and risk of dementia: case-control study” view here utilized 14,453 patients with dementia and 86,403 controls from the UK Clinical Practice Research Datalink.
Both studies observed a robust relationship between the use of drugs with anticholinergic properties and adverse consequences, including dementia, increased risks of visit to emergency departments and risk of fracture. Both studies demonstrate the importance of large electronic health record systems in understanding adverse drug events.
More RSI News
Dr. Mattison chairs NAM report
Compounded medications prepared by pharmacists or physicians have been used extensively throughout history as a mainstay of therapeutics. Over the past half-century – with the…
Country Foods Forum
Leading up to February 11 and 12, 2020, Risk Sciences International had the privilege of assisting Health Canada in its organization of the Country Foods…
Workshop on Evidence Integration December 5-6, 2019
Risk Sciences International is organizing a two day Workshop on Evidence Integration in support of human health risk assessment in collaboration with the McLaughlin Centre…
RSI wins 2019 Consulting Engineers of Ontario Award of Merit
Risk Sciences International (RSI), as members of a consulting team with Stantec, along with the Ontario First Nations Technical Services Corporation (OFNTSC), has won an Award of Merit from the…