Publication related to RSI or an RSI staff member
Relationships between fine particulate air pollution, cardiometabolic disorders, and cardiovascular mortality.
RATIONALE: Growing evidence suggests that long-term exposure to fine particulate matter (PM2.5) air pollution contributes to risk of cardiovascular disease (CVD) morbidity and mortality. There is uncertainty about who are most susceptible. Individuals with underlying cardiometabolic disorders, including hypertension, diabetes mellitus, and obesity, may be at greater risk. PM2.5 pollution may also contribute to cardiometabolic disorders, augmenting CVD risk. OBJECTIVE: This analysis evaluates relationships between long-term PM2.5 exposure and cardiometabolic disease on risk of death from CVD and cardiometabolic conditions. METHODS AND RESULTS: Data on 669 046 participants from the American Cancer Society Cancer Prevention Study II cohort were linked to modeled PM2.5 concentrations at geocoded home addresses. Cox proportional hazards regression models were used to estimate adjusted hazards ratios for death from CVD and cardiometabolic diseases based on death-certificate information. Effect modification by pre-existing cardiometabolic risk factors on the PM2.5-CVD mortality association was examined. PM2.5 exposure was associated with CVD mortality, with the hazards ratios (95% confidence interval) per 10 mug/m(3) increase in PM2.5 equal to 1.12 (1.10-1.15). Deaths linked to hypertension and diabetes mellitus (mentioned on death certificate as either primary or contributing cause of death) were also associated with PM2.5. There was no consistent evidence of effect modification by cardiometabolic disease risk factors on the PM2.5-CVD mortality association. CONCLUSIONS: Pollution-induced CVD mortality risk is observed for those with and without existing cardiometabolic disorders. Long-term exposure may also contribute to the development or exacerbation of cardiometabolic disorders, increasing risk of CVD, and cardiometabolic disease mortality.
Authors
- Pope, C Arden 3rd, Pope CA 3rd, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.). cap3@byu.edu.
- Turner, Michelle C, Turner MC, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.).
- Burnett, Richard T, Burnett RT, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.).
- Jerrett, Michael, Jerrett M, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.).
- Gapstur, Susan M, Gapstur SM, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.).
- Diver, W Ryan, Diver WR, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.).
- Krewski, Daniel, Krewski D, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.).
- Brook, Robert D, Brook RD, From the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health (M.C.T., D.K.) and Department of Epidemiology and Community Medicine, Faculty of Medicine (D.K.), University of Ottawa, Ottawa, Ontario, Canada; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (M.C.T.); CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain (M.C.T.); Universitat Pompeu Fabra, Barcelona, Spain (M.C.T.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley (M.J.); Epidemiology Research Program, American Cancer Society, Atlanta, GA (S.M.G., W.R.D.); Risk Sciences International, Ottawa, Ontario, Canada (D.K.); and Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor (R.D.B.).
YEAR OF PUBLICATION: 2015
SOURCE: Circ Res. 2015 Jan 2;116(1):108-15. doi: 10.1161/CIRCRESAHA.116.305060. Epub 2014 Oct 27.
JOURNAL TITLE ABBREVIATION: Circ Res
JOURNAL TITLE: Circulation research
ISSN: 1524-4571 (Electronic) 0009-7330 (Linking)
VOLUME: 116
ISSUE: 1
PAGES: 108-15
PLACE OF PUBLICATION: United States
ABSTRACT:
RATIONALE: Growing evidence suggests that long-term exposure to fine particulate matter (PM2.5) air pollution contributes to risk of cardiovascular disease (CVD) morbidity and mortality. There is uncertainty about who are most susceptible. Individuals with underlying cardiometabolic disorders, including hypertension, diabetes mellitus, and obesity, may be at greater risk. PM2.5 pollution may also contribute to cardiometabolic disorders, augmenting CVD risk. OBJECTIVE: This analysis evaluates relationships between long-term PM2.5 exposure and cardiometabolic disease on risk of death from CVD and cardiometabolic conditions. METHODS AND RESULTS: Data on 669 046 participants from the American Cancer Society Cancer Prevention Study II cohort were linked to modeled PM2.5 concentrations at geocoded home addresses. Cox proportional hazards regression models were used to estimate adjusted hazards ratios for death from CVD and cardiometabolic diseases based on death-certificate information. Effect modification by pre-existing cardiometabolic risk factors on the PM2.5-CVD mortality association was examined. PM2.5 exposure was associated with CVD mortality, with the hazards ratios (95% confidence interval) per 10 mug/m(3) increase in PM2.5 equal to 1.12 (1.10-1.15). Deaths linked to hypertension and diabetes mellitus (mentioned on death certificate as either primary or contributing cause of death) were also associated with PM2.5. There was no consistent evidence of effect modification by cardiometabolic disease risk factors on the PM2.5-CVD mortality association. CONCLUSIONS: Pollution-induced CVD mortality risk is observed for those with and without existing cardiometabolic disorders. Long-term exposure may also contribute to the development or exacerbation of cardiometabolic disorders, increasing risk of CVD, and cardiometabolic disease mortality.
RATIONALE: Growing evidence suggests that long-term exposure to fine particulate matter (PM2.5) air pollution contributes to risk of cardiovascular disease (CVD) morbidity and mortality. There is uncertainty about who are most susceptible. Individuals with underlying cardiometabolic disorders, including hypertension, diabetes mellitus, and obesity, may be at greater risk. PM2.5 pollution may also contribute to cardiometabolic disorders, augmenting CVD risk. OBJECTIVE: This analysis evaluates relationships between long-term PM2.5 exposure and cardiometabolic disease on risk of death from CVD and cardiometabolic conditions. METHODS AND RESULTS: Data on 669 046 participants from the American Cancer Society Cancer Prevention Study II cohort were linked to modeled PM2.5 concentrations at geocoded home addresses. Cox proportional hazards regression models were used to estimate adjusted hazards ratios for death from CVD and cardiometabolic diseases based on death-certificate information. Effect modification by pre-existing cardiometabolic risk factors on the PM2.5-CVD mortality association was examined. PM2.5 exposure was associated with CVD mortality, with the hazards ratios (95% confidence interval) per 10 mug/m(3) increase in PM2.5 equal to 1.12 (1.10-1.15). Deaths linked to hypertension and diabetes mellitus (mentioned on death certificate as either primary or contributing cause of death) were also associated with PM2.5. There was no consistent evidence of effect modification by cardiometabolic disease risk factors on the PM2.5-CVD mortality association. CONCLUSIONS: Pollution-induced CVD mortality risk is observed for those with and without existing cardiometabolic disorders. Long-term exposure may also contribute to the development or exacerbation of cardiometabolic disorders, increasing risk of CVD, and cardiometabolic disease mortality.
COPYRIGHT INFORMATION: (c) 2014 American Heart Association, Inc.
LANGUAGE: eng
DATE OF PUBLICATION: 2015 Jan 2
DATE OF ELECTRONIC PUBLICATION: 20141027
DATE COMPLETED: 20150320
DATE REVISED: 20220410
MESH DATE: 2015/03/21 06:00
EDAT: 2014/10/29 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: 10.1161/CIRCRESAHA.116.305060 [doi]
OWNER: NLM
Related RSI Experts
Chief Risk Scientist
Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...