A Risk Sciences International Case Study

Measuring impact of zoonotic animal diseases in Canada

RSI was involved with the study of the impact of zoonotic animal diseases in Canada.

Client: Canadian Food Inspection Agency (CFIA)

Listing of the client in no way affirms the client's support, sponsorship, or validation in any form of Risk Sciences International or the RSI staff member(s) who conducted this project during their stay with RSI or prior to joining the company. This case study is displayed for informative purposes only to demonstrate the capacity of RSI staff members. This case study reveals no proprietary information or information deemed sensitive.

Project description:

Measuring impact of zoonotic animal diseases in Canada

The Canadian Food Inspection Agency sought RSI’s support in exploring how human health impacts from zoonotic diseases could be compared consistently with other public health risks. Traditionally, animal disease control decisions relied on veterinary and economic measures, but there was no standard way to capture and compare the burden of zoonoses on human health. The CFIA wanted an approach that would allow it to weigh different animal health interventions against other public health priorities in a way that was scientifically robust and comparable across hazards.

RSI conducted case studies on a range of zoonotic diseases, including avian influenza, bovine spongiform encephalopathy, bovine tuberculosis, brucellosis, psittacosis, Q fever, Rift Valley fever, and others. For each, data were compiled and modeled using stochastic calculations with @Risk software, with bootstrapped iterations to quantify uncertainty. Human health impacts were expressed in disability adjusted life years (DALYs), an established metric used by the World Health Organization and others to capture both morbidity and mortality in a single measure. This allowed the CFIA to see the relative health burden of animal diseases compared not only to each other but also to other human health risks outside the veterinary domain.

The purpose of this project was to provide the CFIA with a decision-support basis for prioritizing interventions across a wide range of zoonotic hazards. By translating animal health risks into DALYs, the agency gained a tool for consistent cross-comparison, enabling more balanced and defensible risk management choices and more transparent communication of risk trade-offs to stakeholders.

Experts related to this case study

Greg Paoli

CEO, Principal Risk Scientist

Greg Paoli is the CEO and Principal Risk Scientist at Risk Sciences International (RSI), a firm he co-founded in 2006 following the integration of his earlier consultancy, Decisionalysis Risk Consultants, with the consulting activities of the McLaughlin Centre for Population...
Read More about Greg Paoli

Emma Hartnett

Vice-President Risk Modelling and Simulation

Dr. Emma Hartnett is Vice-President, Risk Modelling and Simulation at Risk Sciences International (RSI), where she has been a foundational member since its inception in 2006. A globally recognized authority in quantitative risk assessment (QRA), she specializes in developing risk...
Read More about Emma Hartnett

Michael G. Tyshenko

Senior Health Risk Analyst

Dr. Michael G. Tyshenko is a Senior Health Risk Analyst at Risk Sciences International (RSI), where he has contributed since 2018 to some of the organization’s most complex and cross-cutting public health risk projects. As RSI’s lead on chemical peer...
Read More about Michael G. Tyshenko

More RSI Case Studies

RSI presents a very small selection of case studies to highlight some of its key work.

Marine Planning and Conservation National Ecological Risk Guidance: Risk Communication Expertise

To support the refinement and implementation of its ecological risk guidance, a federal department responsible for marine conservation engaged expert assistance in risk communication. The primary objective was to ensure that the national guidance for ecological risk assessment—developed as part...
Read More about Marine Planning and Conservation National Ecological Risk Guidance: Risk Communication Expertise

External Peer Consultation of the Inorganic – Late Biomonitoring Approach Draft Screening Assessment Report

To support the Chemicals Management Plan under the Canadian Environmental Protection Act (CEPA), Health Canada sought expert peer consultation for a draft screening assessment report (DSAR) evaluating 47 inorganic substances identified as priorities. The client required independent scientific and technical...
Read More about External Peer Consultation of the Inorganic – Late Biomonitoring Approach Draft Screening Assessment Report

EFSA Framework for Problem Formulation

To enhance the methodological rigour of its scientific assessments, EFSA sought to develop a standardised framework for problem formulation (PF) within its non-application scientific assessment protocols. The goal was to support the planning phase of these assessments by establishing a...
Read More about EFSA Framework for Problem Formulation

Assessing the Impact of Interstudy Variation in LOAELs on Findings of Low-Dose Additivity in In Vivo Studies of Mixtures

Demonstrating the safe use of chemical mixtures remains a critical challenge in toxicological science. In recent years, studies have suggested that chemicals can exhibit dose additivity—causing a combined effect—even when each chemical individually is below its effect threshold. This project...
Read More about Assessing the Impact of Interstudy Variation in LOAELs on Findings of Low-Dose Additivity in In Vivo Studies of Mixtures

International newspaper rethink

The International Herald Tribune (IHT) sought guidance at a time of profound change in the media landscape. With the World Wide Web emerging and competition intensifying from global and regional editions of established outlets such as The Economist, The Wall...
Read More about International newspaper rethink

Systematic Review of Artificial Sweeteners and Health Risks

A comprehensive systematic review was undertaken to assess experimental evidence regarding the potential health risks associated with artificial sweeteners, specifically focusing on cancer and pre-term delivery. The client sought a rigorous analysis of both in vivo and in vitro experimental...
Read More about Systematic Review of Artificial Sweeteners and Health Risks