Publication related to RSI or an RSI staff member
Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union. An updated analysis considering smoking as the main confounding factor.
Authors
- Kreisheimer, M, Kreisheimer M, Radiobiological Institute, University of Munich, Schillerstrasse 42, 80336 Munich, Germany. michael.kreisheimer@lrz.uni-muenchen.de
- Sokolnikov, M E, Sokolnikov ME,
- Koshurnikova, N A, Koshurnikova NA,
- Khokhryakov, V F, Khokhryakov VF,
- Romanow, S A, Romanow SA,
- Shilnikova, N S, Shilnikova NS,
- Okatenko, P V, Okatenko PV,
- Nekolla, E A, Nekolla EA,
- Kellerer, A M, Kellerer AM,
YEAR OF PUBLICATION: 2003
SOURCE: Radiat Environ Biophys. 2003 Jul;42(2):129-35. doi: 10.1007/s00411-003-0198-3. Epub 2003 Jul 8.
JOURNAL TITLE ABBREVIATION: Radiat Environ Biophys
JOURNAL TITLE: Radiation and environmental biophysics
ISSN: 0301-634X (Print) 0301-634X (Linking)
VOLUME: 42
ISSUE: 2
PAGES: 129-35
PLACE OF PUBLICATION: Germany
ABSTRACT:
A new analysis of lung cancer mortality in a cohort of male Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. The follow-up has been extended until 1999, moreover a new dosimetry system (DOSES2000) has been established. Particular emphasis has been given to a discrimination of the effects of external gamma-exposure and internal alpha-exposure due to incorporated plutonium. This study has also utilized and incorporated the information from a cohort of Mayak reactor workers, who were exposed only externally to gamma-rays. The influence of smoking as the main confounding factor for lung cancer has been studied. The baseline lung cancer mortality rate was not taken from national statistics but was derived from the cohort itself. The estimated excess relative risk for the plutonium alpha-rays was 0.23/Sv (95%CI: 0.16-0.31). The resulting risk coefficient for external gamma-ray exposure was very low with a statistically insignificant estimate of 0.058/Sv (95%CI: -0.072-0.20). The inferred relative risk for smokers was 16.5 (95%CI: 12.6-20.5).
A new analysis of lung cancer mortality in a cohort of male Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. The follow-up has been extended until 1999, moreover a new dosimetry system (DOSES2000) has been established. Particular emphasis has been given to a discrimination of the effects of external gamma-exposure and internal alpha-exposure due to incorporated plutonium. This study has also utilized and incorporated the information from a cohort of Mayak reactor workers, who were exposed only externally to gamma-rays. The influence of smoking as the main confounding factor for lung cancer has been studied. The baseline lung cancer mortality rate was not taken from national statistics but was derived from the cohort itself. The estimated excess relative risk for the plutonium alpha-rays was 0.23/Sv (95%CI: 0.16-0.31). The resulting risk coefficient for external gamma-ray exposure was very low with a statistically insignificant estimate of 0.058/Sv (95%CI: -0.072-0.20). The inferred relative risk for smokers was 16.5 (95%CI: 12.6-20.5).
LANGUAGE: eng
DATE OF PUBLICATION: 2003 Jul
DATE OF ELECTRONIC PUBLICATION: 20030708
DATE COMPLETED: 20040330
DATE REVISED: 20210107
MESH DATE: 2004/03/31 05:00
EDAT: 2003/07/10 05:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
OWNER: NLM
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Senior Health Risk Analyst
Dr. Natalia (Natasha) Shilnikova is a Senior Health Risk Analyst at Risk Sciences International (RSI), where she has contributed since 2011 to some of the organization’s most analytically demanding and policy-relevant projects. With a background in medicine and a PhD...