Publication related to RSI or an RSI staff member
Systemic quinolones and risk of retinal detachment III: a nested case-control study using a US electronic health records database.
Authors
- Taher, Mohamed Kadry, Taher MK, McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada. Mohamed.Taher@uOttawa.ca.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada. Mohamed.Taher@uOttawa.ca.; Risk Sciences International, Ottawa, ON, Canada. Mohamed.Taher@uOttawa.ca.
- Crispo, James A G, Crispo JAG, McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Human Sciences Division, Northern Ontario School of Medicine, Sudbury, ON, Canada.
- Fortin, Yannick, Fortin Y, McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.; Statistics Canada, Ottawa, ON, Canada.
- Moog, Ryan, Moog R, Cerner Corporation, Kansas City, MO, USA.
- McNair, Douglas, McNair D, Melinda Gates Foundation, Seattle, WA, USA.
- Bjerre, Lise M, Bjerre LM, School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.; Department of Family Medicine, University of Ottawa, Ottawa, ON, Canada.; Institut du Savoir Montfort, Ottawa, ON, Canada.
- Momoli, Franco, Momoli F, School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.; Risk Sciences International, Ottawa, ON, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
- Mattison, Donald, Mattison D, McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.; Risk Sciences International, Ottawa, ON, Canada.
- Krewski, Daniel, Krewski D, McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Room 216, 600 Peter Morand Crescent, Ottawa, ON, K1G 5Z3, Canada.; School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.; Risk Sciences International, Ottawa, ON, Canada.
BACKGROUND: Quinolones are popular antibiotics that are known for their potency, broad coverage, and reasonable safety. Concerns have been raised about a possible association between quinolones and retinal detachment (RD). METHODS: We conducted a nested case-control study using electronic health records (EHR) from the Health Facts(R) Database. The initial cohort included all patients who were admitted between 2000 and 2016, with no history of eye disease, and had a minimum medical history of one year. Eligible cases comprised inpatients who were first admitted with a primary diagnosis of RD between 2010 and 2015. Each eligible case was matched without replacement to five unique controls by sex, race, age, and period-at-risk. We used conditional logistic regression to calculate RD risk, adjusting for exposure to other medications, and major risk factors. RESULTS: We identified 772 cases and 3860 controls. Whereas our primary analysis of all subjects revealed no quinolone-associated RD risk, elevated but non-significant risks were noted in African Americans (ciprofloxacin and levofloxacin), those aged 56-70 years old (moxifloxacin), and women (ciprofloxacin). CONCLUSION: Our study did not identify an elevated RD risk within 30 days following systemic administration of quinolone antibiotics. Suggestions of increased risk observed in some population subgroups warrant further investigation.
