A Risk Sciences International Case Study

Risk Assessment of the Impact of Lethality Standards on Salmonellosis from Ready-to-Eat (RTE) Meat and Poultry Products

Ready to eat food

Client: Food Safety and Inspection Service (FSIS), U.S. Department of Agriculture

Listing of the client in no way affirms the client's support, sponsorship, or validation in any form of Risk Sciences International or the RSI staff member(s) who conducted this project during their stay with RSI or prior to joining the company. This case study is displayed for informative purposes only to demonstrate the capacity of RSI staff members. This case study reveals no proprietary information or information deemed sensitive.

Project description:

Risk Assessment of the Impact of Lethality Standards on Salmonellosis from Ready-to-Eat (RTE) Meat and Poultry Products

To support regulatory decision-making, a comprehensive risk assessment was conducted to evaluate how varying lethality performance standards would impact the public health burden of salmonellosis associated with Ready-to-Eat (RTE) meat and poultry products. The primary objective was to quantify the expected number of cases of illness under different reductions in Salmonella presence across a broad spectrum of RTE product categories.

The assessment focused on modeling the survival of Salmonella spp. from raw material contamination through lethality treatments, incorporating factors such as compliance with standards, thermal process safety margins, pathogen growth during storage, and the extent of consumer reheating. A decision-support model was developed using Analytica® software to simulate the full exposure pathway and estimate illness probabilities per serving and per million kilograms of product.

The model provided estimates under multiple scenarios that varied the intensity of lethality requirements across product categories. Each scenario’s public health implications were analyzed to inform the potential benefits of more stringent standards. The findings offered a quantitative foundation for policy evaluation, highlighting trade-offs between regulatory stringency and projected illness reduction.

Start: 2003

End: 2005

Experts related to this case study

Greg Paoli

CEO, Principal Risk Scientist

Greg Paoli is the CEO and Principal Risk Scientist at Risk Sciences International (RSI), a firm he co-founded in 2006 following the integration of his earlier consultancy, Decisionalysis Risk Consultants, with the consulting activities of the McLaughlin Centre for Population...
Read More about Greg Paoli

Emma Hartnett

Vice-President Risk Modelling and Simulation

Dr. Emma Hartnett is Vice-President, Risk Modelling and Simulation at Risk Sciences International (RSI), where she has been a foundational member since its inception in 2006. A globally recognized authority in quantitative risk assessment (QRA), she specializes in developing risk...
Read More about Emma Hartnett

More RSI Case Studies

RSI presents a very small selection of case studies to highlight some of its key work.

Development of a National Food Safety Information System and Risk Assessment Capacity in Vietnam

Authorities in Vietnam sought targeted expertise to strengthen the country’s ability to detect, assess, and respond to food safety threats. This initiative had two linked objectives: building a comprehensive, transparent, and reliable national food safety information system, and enhancing risk...
Read More about Development of a National Food Safety Information System and Risk Assessment Capacity in Vietnam

External Peer Review of the Draft Screening Assessment Report on Selected C3-C5 Alcohols

To support the quality and defensibility of regulatory decision-making under the Canadian Environmental Protection Act, 1999 (CEPA), Health Canada engaged Risk Sciences International to coordinate an independent external peer review of the Draft Screening Assessment Report (DSAR) for Selected C3-C5...
Read More about External Peer Review of the Draft Screening Assessment Report on Selected C3-C5 Alcohols

Risk Model Framework for Foodborne Campylobacteriosis via Poultry Meat Pathway

To support national public health goals, RSI was tasked with developing a quantitative microbiological risk assessment (QMRA) model to estimate the human health risks associated with the consumption of chicken in New Zealand. The core objective was to quantify the...
Read More about Risk Model Framework for Foodborne Campylobacteriosis via Poultry Meat Pathway

Measuring impact of zoonotic animal diseases in Canada

The Canadian Food Inspection Agency sought RSI’s support in exploring how human health impacts from zoonotic diseases could be compared consistently with other public health risks. Traditionally, animal disease control decisions relied on veterinary and economic measures, but there was...
Read More about Measuring impact of zoonotic animal diseases in Canada

Environmental Public Health Approach (EPHA) to Chemicals Expert Workshop

To advance the Government of Canada’s Chemicals Management Plan (CMP), a virtual expert workshop was planned and hosted to refine and evaluate a Canadian framework for the Environmental Public Health Approach (EPHA) to chemicals. The initiative focused on developing case...
Read More about Environmental Public Health Approach (EPHA) to Chemicals Expert Workshop

Analysis in Support of Risk-Based Decision-Making for the Alberta Safety Codes Council

An independent regulatory organization responsible for oversight of Alberta’s safety codes system sought to strengthen its capacity for risk-based decision-making. The organization aimed to ensure that regulatory actions—particularly in the area of petroleum storage tanks—were guided by clear, evidence-based prioritization...
Read More about Analysis in Support of Risk-Based Decision-Making for the Alberta Safety Codes Council

Pickering Nuclear Facility Re‑licensing

The client sought support to finalize a Commission Member Document (CMD) for the re‑licensing of a nuclear facility. Recognizing the complexity and sensitivity of reactor re‑licensing, they requested assistance in crafting communication materials that were both technically comprehensive and accessible...
Read More about Pickering Nuclear Facility Re‑licensing

Assessing the Impact of Interstudy Variation in LOAELs on Findings of Low-Dose Additivity in In Vivo Studies of Mixtures

Demonstrating the safe use of chemical mixtures remains a critical challenge in toxicological science. In recent years, studies have suggested that chemicals can exhibit dose additivity—causing a combined effect—even when each chemical individually is below its effect threshold. This project...
Read More about Assessing the Impact of Interstudy Variation in LOAELs on Findings of Low-Dose Additivity in In Vivo Studies of Mixtures

Methodology for Developing Risk Significance Insights

The project centered on supporting the development of a methodology that could eventually be implemented as an Artificial Intelligence (AI) or Machine Learning (ML) process. The objective was to help formalize and potentially automate how professional judgment is applied when...
Read More about Methodology for Developing Risk Significance Insights

Update of WHO Guidance on Food Defense

To support international efforts in mitigating deliberate threats to the food system, the World Health Organization commissioned an update to its earlier guidance titled Terrorist Threats to Food. The revision aimed to broaden the original scope by addressing not only...
Read More about Update of WHO Guidance on Food Defense

Risk-Based Decision Making (RBDM) Compliance and Enforcement

Innovation, Science and Economic Development Canada (ISED), through its Spectrum Management Innovation Directorate, sought support in applying risk-based decision making (RBDM) across its compliance and enforcement responsibilities. The department was looking for a structured and data-driven approach to prioritize regulatory...
Read More about Risk-Based Decision Making (RBDM) Compliance and Enforcement

Age-Related Cognitive Decline: Systematic Review and Meta-Analysis

The College of Physicians & Surgeons of Alberta (CPSA) commissioned a systematic review and meta-analysis to support evidence-informed decision-making around age-related cognitive decline among practicing physicians. The initiative was led by CPSA’s Physician Health Monitoring Program (PHMP), which sought to...
Read More about Age-Related Cognitive Decline: Systematic Review and Meta-Analysis

Evaluation of Toxicological Data on Experior

To support the evaluation of a new veterinary pharmaceutical product intended for use in bovines, a scientific review was requested of submitted toxicological data related to the active compound LY488756. This compound, proposed under the product name Experior, had been...
Read More about Evaluation of Toxicological Data on Experior

Contraceptive recall review

Health Canada requested an external review following significant public criticism of its handling of a pharmaceutical recall. The case involved a contraceptive drug that was withdrawn due to packaging errors, and the department faced questions about whether it had acted...
Read More about Contraceptive recall review

Marine Planning and Conservation National Ecological Risk Guidance: Risk Communication Expertise

To support the refinement and implementation of its ecological risk guidance, a federal department responsible for marine conservation engaged expert assistance in risk communication. The primary objective was to ensure that the national guidance for ecological risk assessment—developed as part...
Read More about Marine Planning and Conservation National Ecological Risk Guidance: Risk Communication Expertise

Risk Communication on McIntyre Powder

In response to increasing public concern about the historical use of McIntyre Powder—an aluminum-based substance once administered to miners in Ontario to prevent silicosis—the client sought expert guidance on managing risk communication related to potential health implications. Widespread media coverage...
Read More about Risk Communication on McIntyre Powder

Finalization of Risk Assessment on Secure Opioid Dispensing Devices

To support decision-making around modifications to opioid agonist treatment delivery, a detailed risk assessment was requested to evaluate the integration of secure dispensing devices for direct patient access to hydromorphone. Building on a previously conducted preliminary assessment, the work required...
Read More about Finalization of Risk Assessment on Secure Opioid Dispensing Devices