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The vision of toxicity testing in the 21st century: moving from discussion to action.

Over the past year, a series on commentaries have appeared in the Toxicological Sciences Forum Series related to the 2007 National Research Council (NRC) publication, Toxicity Testing in the 21st Century: A Vision and A Strategy. The first article in the series provided an overview of the vision and was accompanied by an editorial by the three editors of Toxicological Sciences. During the past year, eight invited commentaries from the academic, industrial, and regulatory sectors have provided diverse perspectives on the vision, noted challenges to its implementation, and highlighted aspects of toxicity testing that were not addressed in the original NRC report. Here, we offer a summary of the main points raised by the commentators in tabular form, identify a number of common themes, and finish the series by providing our perspective on several key issues in charting the path forward to move from discussion to action.

Authors

  • Andersen, Melvin E, Andersen ME, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA. mandersen@thehamner.org

  • Krewski, Daniel, Krewski D,

YEAR OF PUBLICATION: 2010
SOURCE: Toxicol Sci. 2010 Sep;117(1):17-24. doi: 10.1093/toxsci/kfq188. Epub 2010 Jun 23.
JOURNAL TITLE ABBREVIATION: Toxicol Sci
JOURNAL TITLE: Toxicological sciences : an official journal of the Society of Toxicology
ISSN: 1096-0929 (Electronic) 1096-0929 (Linking)
VOLUME: 117
ISSUE: 1
PAGES: 17-24
PLACE OF PUBLICATION: United States
ABSTRACT:
Over the past year, a series on commentaries have appeared in the Toxicological Sciences Forum Series related to the 2007 National Research Council (NRC) publication, Toxicity Testing in the 21st Century: A Vision and A Strategy. The first article in the series provided an overview of the vision and was accompanied by an editorial by the three editors of Toxicological Sciences. During the past year, eight invited commentaries from the academic, industrial, and regulatory sectors have provided diverse perspectives on the vision, noted challenges to its implementation, and highlighted aspects of toxicity testing that were not addressed in the original NRC report. Here, we offer a summary of the main points raised by the commentators in tabular form, identify a number of common themes, and finish the series by providing our perspective on several key issues in charting the path forward to move from discussion to action.
LANGUAGE: eng
DATE OF PUBLICATION: 2010 Sep
DATE OF ELECTRONIC PUBLICATION: 20100623
DATE COMPLETED: 20101210
DATE REVISED: 20250124
MESH DATE: 2010/12/14 06:00
EDAT: 2010/06/25 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: 10.1093/toxsci/kfq188 [doi]
OWNER: NLM

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Daniel Krewski

Chief Risk Scientist

Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...
Read More about Daniel Krewski