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The INTEROCC case-control study: risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents.
BACKGROUND: Little is known about occupational risk factors for meningioma. OBJECTIVES: To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents. METHODS: The INTEROCC study was an international case-control study of brain cancer conducted in seven countries. Data collection by interview included lifetime occupational histories. A job exposure matrix was used to derive estimates of exposure for the 12 agents. ORs for ever versus never exposed and for exposure-response using duration of exposure and cumulative exposure were derived using conditional logistic regression stratified by sex, age group, country/region, adjusted for education. RESULTS: These analyses included 1906 cases and 5565 controls. For 11 of the 12 agents, no excess risk was found for ever exposed. For ever exposure to oil mists, an elevated OR of 1.57 (95% CI 1.10 to 2.22, 51 exposed cases) was found. Statistically significant exposure-response relationships were observed with cumulative exposure (p=0.01) and duration of exposure (p=0.04). Among women, there were also significant trends for cumulative and duration of exposure to asbestos and excesses in the highest exposure categories for formaldehyde. CONCLUSIONS: Most agents examined did not provoke excess risks of meningioma. The main finding from this study is that it is the first study to identify a statistical association between exposure to oil mists and meningioma. This may be a chance finding or could be due to confounding with iron exposure and further research is required to understand whether the relationship is causal.
Authors
- McElvenny, Damien M, McElvenny DM, Institute of Occupational Medicine, Edinburgh, UK.
- van Tongeren, Martie, van Tongeren M, Institute of Occupational Medicine, Edinburgh, UK.; Centre for Occupational and Environmental Health, Centre for Epidemiology, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, UK.
- Turner, Michelle C, Turner MC, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada.
- Benke, Geza, Benke G, Monash University, Melbourne, Australia.
- Figuerola, Jordi, Figuerola J, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
- Fleming, Sarah, Fleming S, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
- Hours, Martine, Hours M, Unité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR, Université de Lyon, Lyon, France.
- Kincl, Laurel, Kincl L, College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, USA.
- Krewski, Daniel, Krewski D, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada.; Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
- McLean, Dave, McLean D, Centre for Public Health Research, Massey University, Wellington, New Zealand.
- Parent, Marie-Elise, Parent ME, INRS-Institut Armand-Frappier, Université du Québec, Laval, Canada.
- Richardson, Lesley, Richardson L, University of Montreal Hospital Research Centre, Montreal, Canada.
- Schlehofer, Brigitte, Schlehofer B, Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany.
- Schlaefer, Klaus, Schlaefer K, Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany.
- Sadetzki, Siegal, Sadetzki S, The Cancer & Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
- Schuz, Joachim, Schuz J, International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France.
- Siemiatycki, Jack, Siemiatycki J, University of Montreal Hospital Research Centre, Montreal, Canada.
- Cardis, Elisabeth, Cardis E, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
BACKGROUND: Little is known about occupational risk factors for meningioma. OBJECTIVES: To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents. METHODS: The INTEROCC study was an international case-control study of brain cancer conducted in seven countries. Data collection by interview included lifetime occupational histories. A job exposure matrix was used to derive estimates of exposure for the 12 agents. ORs for ever versus never exposed and for exposure-response using duration of exposure and cumulative exposure were derived using conditional logistic regression stratified by sex, age group, country/region, adjusted for education. RESULTS: These analyses included 1906 cases and 5565 controls. For 11 of the 12 agents, no excess risk was found for ever exposed. For ever exposure to oil mists, an elevated OR of 1.57 (95% CI 1.10 to 2.22, 51 exposed cases) was found. Statistically significant exposure-response relationships were observed with cumulative exposure (p=0.01) and duration of exposure (p=0.04). Among women, there were also significant trends for cumulative and duration of exposure to asbestos and excesses in the highest exposure categories for formaldehyde. CONCLUSIONS: Most agents examined did not provoke excess risks of meningioma. The main finding from this study is that it is the first study to identify a statistical association between exposure to oil mists and meningioma. This may be a chance finding or could be due to confounding with iron exposure and further research is required to understand whether the relationship is causal.
