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The influence of the environment and other exogenous agents on spontaneous abortion risk.
It is estimated that close to 30% of all pregnancies end in spontaneous abortion. Although about 60% of spontaneous abortions are thought to be due to genetic, infectious, hormonal, and immunological factors, the role of the environment remains poorly understood. Pregnancy involves a delicate balance of hormonal and immunological functions, which may be affected by environmental substances. Many toxic substances that are persistent in the environment and accumulate in the fatty tissues may disrupt this equilibrium. This overview addresses known risk factors for spontaneous abortions and examines the role, if any, that environmental factors (chemical and physical) may play in the etiology of this adverse health outcome.
Authors
- Weselak, Mandy, Weselak M, McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada. mandy_weselak@hc-sc.gc.ca
- Arbuckle, Tye E, Arbuckle TE,
- Walker, Mark C, Walker MC,
- Krewski, Daniel, Krewski D,
YEAR OF PUBLICATION: 2008
SOURCE: J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):221-41. doi: 10.1080/10937400701873530.
JOURNAL TITLE ABBREVIATION: J Toxicol Environ Health B Crit Rev
JOURNAL TITLE: Journal of toxicology and environmental health. Part B, Critical reviews
ISSN: 1521-6950 (Electronic) 1093-7404 (Linking)
VOLUME: 11
ISSUE: 3-4
PAGES: 221-41
PLACE OF PUBLICATION: England
ABSTRACT:
It is estimated that close to 30% of all pregnancies end in spontaneous abortion. Although about 60% of spontaneous abortions are thought to be due to genetic, infectious, hormonal, and immunological factors, the role of the environment remains poorly understood. Pregnancy involves a delicate balance of hormonal and immunological functions, which may be affected by environmental substances. Many toxic substances that are persistent in the environment and accumulate in the fatty tissues may disrupt this equilibrium. This overview addresses known risk factors for spontaneous abortions and examines the role, if any, that environmental factors (chemical and physical) may play in the etiology of this adverse health outcome.
It is estimated that close to 30% of all pregnancies end in spontaneous abortion. Although about 60% of spontaneous abortions are thought to be due to genetic, infectious, hormonal, and immunological factors, the role of the environment remains poorly understood. Pregnancy involves a delicate balance of hormonal and immunological functions, which may be affected by environmental substances. Many toxic substances that are persistent in the environment and accumulate in the fatty tissues may disrupt this equilibrium. This overview addresses known risk factors for spontaneous abortions and examines the role, if any, that environmental factors (chemical and physical) may play in the etiology of this adverse health outcome.
LANGUAGE: eng
DATE OF PUBLICATION: 2008 Mar
DATE COMPLETED: 20080411
DATE REVISED: 20080327
MESH DATE: 2008/04/12 09:00
EDAT: 2008/03/28 09:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: 10.1080/10937400701873530 [doi]
OWNER: NLM
Related RSI Experts
Chief Risk Scientist
Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...