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The impact of pregnancy on postoperative outcomes among obese women who underwent bariatric surgery: A systematic review and meta-analysis.

OBJECTIVES: Women who had a history of bariatric surgery are increasingly becoming pregnant. There is growing evidence showing that increased risk of postoperative complications may be associated with the gestation after bariatric surgery.The objective of this systematic review was to evaluate the potential impact of pregnancy on weight loss and postoperative complications in obese women after bariatric surgery. STUDY DESIGN: PubMed, Embase, Medline and Cochrane Central Register of Controlled Trails were searched from inception through October 2018. Selection criteria included observational or randomized trial examining weight loss and medical complications in pregnant compared to non-pregnant women after bariatric surgery. Two reviewers extracted information and performed quality appraisal of eligible articles. Meta-analysis was performed to ascertain the certainty of the evidence when possible. RESULTS: Seven observational cohort studies with a total of 27,369 obese women were included in the final analysis. The mean difference (95 % confidence interval) in percent excess weight loss between pregnant and non-pregnant subjects was -9.5 (-19.9, 0.9). The odds ratio (95 % confidence interval) for postoperative complications in pregnant relative to non-pregnant subjects was 0.85 (0.33, 2.18). CONCLUSIONS: Pregnancy may have little or no effect on weight loss or postoperative complications in women who have undergone bariatric surgery.

Authors

  • Yang, Siyu, Yang S, Nursing School of Central South University, Changsha, Hunan, PR China. Electronic address: ysy94@foxmail.com.

  • Zhou, Leshan, Zhou L, Nursing School of Central South University, Changsha, Hunan, PR China. Electronic address: leshanzhou@csu.edu.cn.

  • Chen, Yijing, Chen Y, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China; Wuhan Mental Health Center affiliated Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.

  • Krewski, Daniel, Krewski D, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.

  • Xie, Ri-Hua, Xie RH, Department of Nursing, General Practice Center Nanhai Hospital, Southern Medical University, Guangzhou, PR China. Electronic address: xierihua928@hotmail.com.

  • Wen, Shi Wu, Wen SW, School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada; OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa Faculty of Medicine, Ottawa, Canada. Electronic address: swwen@ohri.ca.

YEAR OF PUBLICATION: 2020
SOURCE: Eur J Obstet Gynecol Reprod Biol. 2020 Sep;252:239-245. doi: 10.1016/j.ejogrb.2020.06.044. Epub 2020 Jun 23.
JOURNAL TITLE ABBREVIATION: Eur J Obstet Gynecol Reprod Biol
JOURNAL TITLE: European journal of obstetrics, gynecology, and reproductive biology
ISSN: 1872-7654 (Electronic) 0301-2115 (Linking)
VOLUME: 252
PAGES: 239-245
PLACE OF PUBLICATION: Ireland
ABSTRACT:
OBJECTIVES: Women who had a history of bariatric surgery are increasingly becoming pregnant. There is growing evidence showing that increased risk of postoperative complications may be associated with the gestation after bariatric surgery.The objective of this systematic review was to evaluate the potential impact of pregnancy on weight loss and postoperative complications in obese women after bariatric surgery. STUDY DESIGN: PubMed, Embase, Medline and Cochrane Central Register of Controlled Trails were searched from inception through October 2018. Selection criteria included observational or randomized trial examining weight loss and medical complications in pregnant compared to non-pregnant women after bariatric surgery. Two reviewers extracted information and performed quality appraisal of eligible articles. Meta-analysis was performed to ascertain the certainty of the evidence when possible. RESULTS: Seven observational cohort studies with a total of 27,369 obese women were included in the final analysis. The mean difference (95 % confidence interval) in percent excess weight loss between pregnant and non-pregnant subjects was -9.5 (-19.9, 0.9). The odds ratio (95 % confidence interval) for postoperative complications in pregnant relative to non-pregnant subjects was 0.85 (0.33, 2.18). CONCLUSIONS: Pregnancy may have little or no effect on weight loss or postoperative complications in women who have undergone bariatric surgery.
COPYRIGHT INFORMATION: Copyright (c) 2020. Published by Elsevier B.V.
LANGUAGE: eng
DATE OF PUBLICATION: 2020 Sep
DATE OF ELECTRONIC PUBLICATION: 20200623
DATE COMPLETED: 20210514
DATE REVISED: 20250522
MESH DATE: 2021/05/15 06:00
EDAT: 2020/07/06 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: S0301-2115(20)30419-X [pii] 10.1016/j.ejogrb.2020.06.044 [doi]
OWNER: NLM

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Daniel Krewski

Chief Risk Scientist

Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...
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