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Physical activity levels, pulmonary function, and MRI in children born extremely preterm: A comparison between children with and without bronchopulmonary dysplasia.
INTRODUCTION: Children with a history of bronchopulmonary dysplasia (BPD) may have lower physical activity levels, but evidence to date is mixed. This study compared physical activity levels between children born extremely preterm with and without history of BPD, and examined their associations with pulmonary magnetic resonance imaging (MRI) and pulmonary function test (PFT) indices. METHODS: This multicentre cross-sectional study included children aged 7-9 years born extremely preterm, with and without BPD. Children wore a pedometer for 1 week, then completed the Physical Activity Questionnaire (PAQ), pulmonary MRI, and PFT. Spearman correlations and multivariable linear regression modeling were performed. RESULTS: Of 45 children, 28 had a history of moderate-severe BPD. There were no differences in any physical activity outcomes by BPD status. Higher average daily step count and higher average daily moderate-to-vigorous physical activity (MVPA) were each correlated with greater forced vital capacity (r = 0.41 and 0.58), greater MRI lung proton density at full expiration (r = 0.42 and 0.49), and lower lung clearance index (r = -0.50 and -0.41). After adjusting for MRI total proton density and BPD status, a 5% increase in forced expiratory volume at 1 s was associated with 738 (95% CI: 208, 1268) more steps per day and 0.1 (0.0, 0.2) more hours of MVPA, respectively. CONCLUSION: School-aged children born extremely preterm have similar physical activity levels to their peers, regardless of history of BPD. MRI and PFT measures suggestive of gas trapping and/or airflow obstruction are associated with lower physical activity levels.
Authors
- Roeper, Rhiana, Roeper R, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
- Blinder, Henrietta, Blinder H, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Hayawi, Lamia, Hayawi L, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Barrowman, Nicholas, Barrowman N, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Luu, Thuy Mai, Luu TM, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
- Moraes, Theo J, Moraes TJ, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Translational Medicine Program, Hospital for Sick Children, Toronto, Ontario, Canada.
- Tse, Sze Man, Tse SM, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
- Parraga, Grace, Parraga G, Department of Medical Biophysics, Western University, London, Ontario, Canada.; Robarts Research Institute, London, Ontario, Canada.
- Santyr, Giles, Santyr G, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Translational Medicine Program, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
- Chaput, Jean-Philippe, Chaput JP, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Momoli, Franco, Momoli F, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Thebaud, Bernard, Thebaud B, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
- Abdeen, Nishard, Abdeen N, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
- Deschenes, Sylvain, Deschenes S, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
- Couch, Marcus J, Couch MJ, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Siemens Healthcare Limited, Montreal, Quebec, Canada.
- Nuyt, Anne-Monique, Nuyt AM, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
- Fadel, Nadya B, Fadel NB, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Katz, Sherri L, Katz SL, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
INTRODUCTION: Children with a history of bronchopulmonary dysplasia (BPD) may have lower physical activity levels, but evidence to date is mixed. This study compared physical activity levels between children born extremely preterm with and without history of BPD, and examined their associations with pulmonary magnetic resonance imaging (MRI) and pulmonary function test (PFT) indices. METHODS: This multicentre cross-sectional study included children aged 7-9 years born extremely preterm, with and without BPD. Children wore a pedometer for 1 week, then completed the Physical Activity Questionnaire (PAQ), pulmonary MRI, and PFT. Spearman correlations and multivariable linear regression modeling were performed. RESULTS: Of 45 children, 28 had a history of moderate-severe BPD. There were no differences in any physical activity outcomes by BPD status. Higher average daily step count and higher average daily moderate-to-vigorous physical activity (MVPA) were each correlated with greater forced vital capacity (r = 0.41 and 0.58), greater MRI lung proton density at full expiration (r = 0.42 and 0.49), and lower lung clearance index (r = -0.50 and -0.41). After adjusting for MRI total proton density and BPD status, a 5% increase in forced expiratory volume at 1 s was associated with 738 (95% CI: 208, 1268) more steps per day and 0.1 (0.0, 0.2) more hours of MVPA, respectively. CONCLUSION: School-aged children born extremely preterm have similar physical activity levels to their peers, regardless of history of BPD. MRI and PFT measures suggestive of gas trapping and/or airflow obstruction are associated with lower physical activity levels.
