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Interrater reliability of the modified Jadad quality scale for systematic reviews of Alzheimer’s disease drug trials.

Drug therapies for Alzheimer’s disease (AD) have been evaluated in clinical trials over the past 2 decades. Systematic reviews of AD drug trials can shed more light on the efficacy of pharmaceutical interventions. The modified Jadad scale can be used to assess the quality of trial reports that are candidates for inclusion in these systematic reviews. The interrater reliability of the modified Jadad scale was examined during such a review. Three blinded reviewers rated the quality of 42 AD drug trial reports: the intraclass correlation coefficient was 0.90. The modified Jadad scale appears to be a useful tool for AD research because of the very good interrater reliability. Also, it is composed of items that are well suited to the specific disease characteristics of AD. Further research should focus on the validity of this instrument.

Authors

  • Oremus, M, Oremus M, Center for Clinical Epidemiology and Community Studies, S.M.B.D. Jewish General Hospital, Montreal, Canada.

  • Wolfson, C, Wolfson C,

  • Perrault, A, Perrault A,

  • Demers, L, Demers L,

  • Momoli, F, Momoli F,

  • Moride, Y, Moride Y,

YEAR OF PUBLICATION: 2001
SOURCE: Dement Geriatr Cogn Disord. 2001 May-Jun;12(3):232-6. doi: 10.1159/000051263.
JOURNAL TITLE ABBREVIATION: Dement Geriatr Cogn Disord
JOURNAL TITLE: Dementia and geriatric cognitive disorders
ISSN: 1420-8008 (Print) 1420-8008 (Linking)
VOLUME: 12
ISSUE: 3
PAGES: 232-6
PLACE OF PUBLICATION: Switzerland
ABSTRACT:
Drug therapies for Alzheimer's disease (AD) have been evaluated in clinical trials over the past 2 decades. Systematic reviews of AD drug trials can shed more light on the efficacy of pharmaceutical interventions. The modified Jadad scale can be used to assess the quality of trial reports that are candidates for inclusion in these systematic reviews. The interrater reliability of the modified Jadad scale was examined during such a review. Three blinded reviewers rated the quality of 42 AD drug trial reports: the intraclass correlation coefficient was 0.90. The modified Jadad scale appears to be a useful tool for AD research because of the very good interrater reliability. Also, it is composed of items that are well suited to the specific disease characteristics of AD. Further research should focus on the validity of this instrument.
COPYRIGHT INFORMATION: Copyright 2001 S. Karger AG, Basel.
LANGUAGE: eng
DATE OF PUBLICATION: 2001 May-Jun
DATE COMPLETED: 20010628
DATE REVISED: 20220410
MESH DATE: 2001/06/29 10:01
EDAT: 2001/03/13 10:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
OWNER: NLM

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Franco Momoli

Vice-President Chemical and Product Safety
Dr. Franco Momoli joined Risk Sciences International (RSI) in 2019 and currently serves as Vice-President, Chemical and Product Safety. In this role, he leads a multidisciplinary team of epidemiologists, risk assessors, toxicologists, and biostatisticians in conducting human health risk assessments...
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