Publication related to RSI or an RSI staff member
Exposure to Medical Radiation during Fetal Life, Childhood and Adolescence and Risk of Brain Tumor in Young Age: Results from The MOBI-Kids Case-Control Study.
BACKGROUND: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. METHODS: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10-24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. RESULTS: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44-6.00) and 1.55 (0.57-4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. CONCLUSIONS: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.
Authors
- Pasqual, Elisa, Pasqual E, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
- Castano-Vinyals, Gemma, Castano-Vinyals G, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
- Thierry-Chef, Isabelle, Thierry-Chef I, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
- Kojimahara, Noriko, Kojimahara N, Department of Public Health, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
- Sim, Malcolm R, Sim MR, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
- Kundi, Michael, Kundi M, Department of Environmental Health, Center for Public Health, Medical University Vienna, Vienna, Austria.
- Krewski, Daniel, Krewski D, McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, Ottawa, Ontario, Canada.; Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
- Momoli, Franco, Momoli F, Ottawa Hospital Research Institute, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Lacour, Brigitte, Lacour B, French National Registry of Childhood Solid Tumors, CHRU, Nancy, France.; Inserm U1153, Center of Research in Epidemiology and StatisticS (CRESS), Paris, France.; Paris University, Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Paris, France.
- Remen, Thomas, Remen T, French National Registry of Childhood Solid Tumors, CHRU, Nancy, France.; Inserm U1153, Center of Research in Epidemiology and StatisticS (CRESS), Paris, France.; Paris University, Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Paris, France.
- Radon, Katja, Radon K, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.
- Weinmann, Tobias, Weinmann T, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.
- Petridou, Eleni, Petridou E, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Unit of Clinical Epidemiology, Karolinska Institute, Stockholm, Sweden.
- Moschovi, Maria, Moschovi M, Haematology-Oncology Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
- Dikshit, Rajesh, Dikshit R, Centre for Cancer Epidemiology, Tata Memorial Centre, Mumbai, India.
- Sadetski, Siegal, Sadetski S, Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Ramat Gan, Israel.
- Maule, Milena, Maule M, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy.
- Farinotti, Mariangela, Farinotti M, Unit of Neuroepidemiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
- Ha, Mina, Ha M, Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea.
- 't Mannetje, Andrea, 't Mannetje A, Centre for Public Health Research, Massey University, Wellington, New Zealand.
- Alguacil, Juan, Alguacil J, CIBER EpidemiologÃa y Salud Pública (CIBERESP), Madrid, Spain.; Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain.
- Aragones, Nuria, Aragones N, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Cancer Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain.
- Vermeulen, Roel, Vermeulen R, Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
- Kromhout, Hans, Kromhout H, Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
- Cardis, Elisabeth, Cardis E, Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain, elisabeth.cardis@isglobal.org.; Universitat Pompeu Fabra (UPF), Barcelona, Spain, elisabeth.cardis@isglobal.org.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, elisabeth.cardis@isglobal.org.
YEAR OF PUBLICATION: 2020
SOURCE: Neuroepidemiology. 2020;54(4):343-355. doi: 10.1159/000506131. Epub 2020 Mar 20.
JOURNAL TITLE ABBREVIATION: Neuroepidemiology
JOURNAL TITLE: Neuroepidemiology
ISSN: 1423-0208 (Electronic) 0251-5350 (Linking)
VOLUME: 54
ISSUE: 4
PAGES: 343-355
PLACE OF PUBLICATION: Switzerland
ABSTRACT:
BACKGROUND: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. METHODS: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10-24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. RESULTS: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44-6.00) and 1.55 (0.57-4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. CONCLUSIONS: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.
BACKGROUND: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. METHODS: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10-24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. RESULTS: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44-6.00) and 1.55 (0.57-4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. CONCLUSIONS: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.
COPYRIGHT INFORMATION: (c) 2020 S. Karger AG, Basel.
LANGUAGE: eng
DATE OF PUBLICATION: 2020
DATE OF ELECTRONIC PUBLICATION: 20200320
DATE COMPLETED: 20210818
DATE REVISED: 20210818
MESH DATE: 2021/08/19 06:00
EDAT: 2020/03/23 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: 10.1159/000506131 [doi]
OWNER: NLM
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