Publication related to RSI or an RSI staff member
Dose-response relationships in carcinogenesis.
Considerable information on the carcinogenic potential of chemical and radiological agents has accumulated from the epidemiological and toxicological studies conducted to date. In this article, we discuss dose-response relationships in carcinogenesis from both empirical and theoretical points of view. Emphasis is placed on the application of biologically based models to describe observed dose-response relationships for exposure to single and multiple agents known to increase cancer risk. The implications of these observations for inferences about possible mechanisms of carcinogenesis are explored.
Authors
- Krewski, D, Krewski D, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario.
- Goddard, M J, Goddard MJ,
- Zielinski, J M, Zielinski JM,
YEAR OF PUBLICATION: 1992
SOURCE: IARC Sci Publ. 1992;(116):579-99.
JOURNAL TITLE ABBREVIATION: IARC Sci Publ
JOURNAL TITLE: IARC scientific publications
ISSN: 0300-5038 (Print) 0300-5038 (Linking)
ISSUE: 116
PAGES: 579-99
PLACE OF PUBLICATION: France
ABSTRACT:
Considerable information on the carcinogenic potential of chemical and radiological agents has accumulated from the epidemiological and toxicological studies conducted to date. In this article, we discuss dose-response relationships in carcinogenesis from both empirical and theoretical points of view. Emphasis is placed on the application of biologically based models to describe observed dose-response relationships for exposure to single and multiple agents known to increase cancer risk. The implications of these observations for inferences about possible mechanisms of carcinogenesis are explored.
Considerable information on the carcinogenic potential of chemical and radiological agents has accumulated from the epidemiological and toxicological studies conducted to date. In this article, we discuss dose-response relationships in carcinogenesis from both empirical and theoretical points of view. Emphasis is placed on the application of biologically based models to describe observed dose-response relationships for exposure to single and multiple agents known to increase cancer risk. The implications of these observations for inferences about possible mechanisms of carcinogenesis are explored.
LANGUAGE: eng
DATE OF PUBLICATION: 1992
DATE COMPLETED: 19921222
DATE REVISED: 20051116
MESH DATE: 1992/01/01 00:01
EDAT: 1992/01/01 00:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
OWNER: NLM
Related RSI Experts
Chief Risk Scientist
Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...