Publication related to RSI or an RSI staff member
Development of an Evidence-Based Risk Assessment Framework.
Authors
- Krewski, Daniel, Krewski D, School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.; McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON, Canada.; Risk Sciences International, Ottawa, ON, Canada.
- Saunders-Hastings, Patrick, Saunders-Hastings P, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, ON, Canada.
- Baan, Robert A, Baan RA, The IARC Monographs Programme, International Agency for Research on Cancer, Lyon, France (retired).
- Barton-Maclaren, Tara S, Barton-Maclaren TS, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada.
- Browne, Patience, Browne P, Organization for Economic Cooperation and Development, Paris, France.
- Chiu, Weihsueh A, Chiu WA, Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.
- Gwinn, Maureen, Gwinn M, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA.
- Hartung, Thomas, Hartung T, Chair for Evidence-based Toxicology and Center for Alternatives to Animal Testing (CAAT), Johns Hopkins University, Baltimore, MD, USA.; CAAT-Europe, University of Konstanz, Konstanz, Germany.
- Kraft, Andrew D, Kraft AD, Center for Public Health and Environmental Assessment, Chemical & Pollutant Assessment Division, US EPA, Washington, DC, USA.
- Lam, Juleen, Lam J, Department of Public Health at California State University, East Bay, CA, USA.
- Lewis, R Jeffrey, Lewis RJ, ExxonMobil Biomedical Sciences, Annandale, NJ, USA (retired).
- Sanaa, Moez, Sanaa M, Agence Nationale Sécurité Sanitaire Alimentaire Nationale, Paris, France.
- Morgan, Rebecca L, Morgan RL, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- Paoli, Greg, Paoli G, Risk Sciences International, Ottawa, ON, Canada.
- Rhomberg, Lorenz, Rhomberg L, Gradient, Boston, MA, USA.
- Rooney, Andrew, Rooney A, Integrative Health Assessments Branch, National Toxicology Program, US National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
- Sand, Salomon, Sand S, Department of Risk and Benefit Assessment, Swedish Food Agency, Uppsala, Sweden.
- Schunemann, Holger J, Schunemann HJ, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
- Straif, Kurt, Straif K, The IARC Monographs Programme, International Agency for Research on Cancer, Lyon, France (retired).; Boston College, Chestnut Hill, MA, USA.; ISGlobal, Barcelona, Spain.
- Thayer, Kristina A, Thayer KA, Center for Public Health and Environmental Assessment, Chemical & Pollutant Assessment Division, US EPA, NC, USA.
- Tsaioun, Katya, Tsaioun K, Evidence-Based Toxicology Collaboration, Johns Hopkins University, Baltimore, MD, USA.
Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from mul-tiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key consider-ations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.
