Publication related to RSI or an RSI staff member
Cobalt and chromium levels in blood and urine following hip resurfacing arthroplasty with the Conserve Plus implant.
BACKGROUND: The purpose of the present study was to determine cobalt and chromium ion levels in the blood and urine of patients in whom a modern-generation metal-on-metal hip resurfacing device had been implanted. METHODS: A total of ninety-seven patients with a Conserve Plus metal-on-metal hip resurfacing implant were followed prospectively for two years. Cobalt and chromium levels in erythrocytes, serum, and urine were measured preoperatively as well as three, six, twelve, and twenty-four months postoperatively. RESULTS: The median serum cobalt and chromium ion levels were 1.04 mug/L (range, 0.31 to 7.42 mug/L) and 2.00 mug/L (range, 0.28 to 10.49 mug/L), respectively, at one year after surgery and 1.08 mug/L (range, 0.44 to 7.13 mug/L) and 1.64 mug/L (range, 0.47 to 10.95 mug/L), respectively, at two years after surgery. The corresponding mean levels (and standard deviations) of serum cobalt and chromium were 1.68 +/- 1.66 mug/L and 2.70 +/- 2.22 mug/L, respectively, at one year after surgery and 1.79 +/- 1.66 mug/L and 2.70 +/- 2.37 mug/L, respectively, at two years after surgery. CONCLUSIONS: These levels compare favorably with other published ion results for metal-on-metal hip resurfacing and replacement implants. No pseudotumors or other adverse soft-tissue reactions were encountered in our study population. Further research is needed to determine the clinical importance of increased cobalt and chromium ion levels in serum and urine following metal-on-metal hip resurfacing.
Authors
- Kim, Paul R, Kim PR, Division of Orthopedics, The Ottawa Hospital-General Campus, Room W1650, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada. pkim@ottawahospital.on.ca
- Beaule, Paul E, Beaule PE,
- Dunbar, Michael, Dunbar M,
- Lee, Joshua K L, Lee JK,
- Birkett, Nicholas, Birkett N,
- Turner, Michelle C, Turner MC,
- Yenugadhati, Nagarajkumar, Yenugadhati N,
- Armstrong, Vic, Armstrong V,
- Krewski, Daniel, Krewski D,
BACKGROUND: The purpose of the present study was to determine cobalt and chromium ion levels in the blood and urine of patients in whom a modern-generation metal-on-metal hip resurfacing device had been implanted. METHODS: A total of ninety-seven patients with a Conserve Plus metal-on-metal hip resurfacing implant were followed prospectively for two years. Cobalt and chromium levels in erythrocytes, serum, and urine were measured preoperatively as well as three, six, twelve, and twenty-four months postoperatively. RESULTS: The median serum cobalt and chromium ion levels were 1.04 mug/L (range, 0.31 to 7.42 mug/L) and 2.00 mug/L (range, 0.28 to 10.49 mug/L), respectively, at one year after surgery and 1.08 mug/L (range, 0.44 to 7.13 mug/L) and 1.64 mug/L (range, 0.47 to 10.95 mug/L), respectively, at two years after surgery. The corresponding mean levels (and standard deviations) of serum cobalt and chromium were 1.68 +/- 1.66 mug/L and 2.70 +/- 2.22 mug/L, respectively, at one year after surgery and 1.79 +/- 1.66 mug/L and 2.70 +/- 2.37 mug/L, respectively, at two years after surgery. CONCLUSIONS: These levels compare favorably with other published ion results for metal-on-metal hip resurfacing and replacement implants. No pseudotumors or other adverse soft-tissue reactions were encountered in our study population. Further research is needed to determine the clinical importance of increased cobalt and chromium ion levels in serum and urine following metal-on-metal hip resurfacing.
