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Clinical presentation of young people (10-24 years old) with brain tumors: results from the international MOBI-Kids study.
INTRODUCTION: We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). METHODS: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. RESULTS: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. CONCLUSIONS: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.
Authors
- Zumel-Marne, Angela, Zumel-Marne A, ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Ciber Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
- Kundi, Michael, Kundi M, Center for Public Health, Department of Environmental Health, Medical University Vienna, Vienna, Austria.
- Castano-Vinyals, Gemma, Castano-Vinyals G, ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Ciber Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
- Alguacil, Juan, Alguacil J, Ciber Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. alguacil@dbasp.uhu.es.; Environmental Epidemiology and Neuroscience Laboratory, RENSMA, Huelva University, Av. Andalucía s/n, E-21071, Huelva, Spain. alguacil@dbasp.uhu.es.
- Petridou, Eleni Th, Petridou ET, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Clinical Epidemiology Unit Karolinska Institutet, Stockholm, Sweden.
- Georgakis, Marios K, Georgakis MK, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
- Morales-Suarez-Varela, Maria, Morales-Suarez-Varela M, Ciber Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Área de Medicina Preventiva y Salud Pública, Universitat de Valencia, Valencia, Spain.
- Sadetzki, Siegal, Sadetzki S, Public Health Services, Ministry of Health, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
- Piro, Sara, Piro S, Environmental and Occupational Epidemiology Branch, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network-ISPRO, Florence, Italy.
- Nagrani, Rajini, Nagrani R, Centre for Cancer Epidemiology, Tata Memorial Centre, Mumbai, India.; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
- Filippini, Graziella, Filippini G, Scientific Director's Office, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
- Hutter, Hans-Peter, Hutter HP, Center for Public Health, Department of Environmental Health, Medical University Vienna, Vienna, Austria.
- Dikshit, Rajesh, Dikshit R, Centre for Cancer Epidemiology, Tata Memorial Centre, Mumbai, India.
- Woehrer, Adelheid, Woehrer A, Institute of Neurology, Medical University Vienna, Vienna, Austria.
- Maule, Milena, Maule M, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy.
- Weinmann, Tobias, Weinmann T, Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.
- Krewski, Daniel, Krewski D, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
- T Mannetje, Andrea, T Mannetje A, Centre for Public Health Research, Massey University, Wellington, New Zealand.
- Momoli, Franco, Momoli F, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
- Lacour, Brigitte, Lacour B, French National Registry of Childhood Solid Tumors, CHU, Nancy, France.; Inserm, Center of Research in Epidemiology and StatisticS (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Paris University, Paris, France.
- Mattioli, Stefano, Mattioli S, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
- Spinelli, John J, Spinelli JJ, Population Oncology, BC Cancer, Vancouver, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, Canada.
- Ritvo, Paul, Ritvo P, School of Kinesiology and Health Science and Department of Psychology, York University, Toronto, Canada.
- Remen, Thomas, Remen T, French National Registry of Childhood Solid Tumors, CHU, Nancy, France.
- Kojimahara, Noriko, Kojimahara N, Department of Public Health, Tokyo Women's Medical University, Tokyo, Japan.
- Eng, Amanda, Eng A, Centre for Public Health Research, Massey University, Wellington, New Zealand.
- Thurston, Angela, Thurston A, Centre for Public Health Research, Massey University, Wellington, New Zealand.
- Lim, Hyungryul, Lim H, Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, South Korea.
- Ha, Mina, Ha M, Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, South Korea.
- Yamaguchi, Naohito, Yamaguchi N, Department of Public Health, Tokyo Women's Medical University, Tokyo, Japan.
- Mohipp, Charmaine, Mohipp C, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.; University of Ottawa, Ottawa, ON, Canada.
- Bouka, Evdoxia, Bouka E, Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
- Eastman, Chelsea, Eastman C, ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Ciber Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
- Vermeulen, Roel, Vermeulen R, Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
- Kromhout, Hans, Kromhout H, Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
- Cardis, Elisabeth, Cardis E, ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; Ciber Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
YEAR OF PUBLICATION: 2020
SOURCE: J Neurooncol. 2020 Apr;147(2):427-440. doi: 10.1007/s11060-020-03437-4. Epub 2020 Mar 3.
JOURNAL TITLE ABBREVIATION: J Neurooncol
JOURNAL TITLE: Journal of neuro-oncology
ISSN: 1573-7373 (Electronic) 0167-594X (Print) 0167-594X (Linking)
VOLUME: 147
ISSUE: 2
PAGES: 427-440
PLACE OF PUBLICATION: United States
ABSTRACT:
INTRODUCTION: We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). METHODS: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. RESULTS: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. CONCLUSIONS: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.
INTRODUCTION: We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). METHODS: Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. RESULTS: Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. CONCLUSIONS: This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.
LANGUAGE: eng
DATE OF PUBLICATION: 2020 Apr
DATE OF ELECTRONIC PUBLICATION: 20200303
DATE COMPLETED: 20210202
DATE REVISED: 20210319
MESH DATE: 2021/02/03 06:00
EDAT: 2020/03/04 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: 10.1007/s11060-020-03437-4 [doi]
OWNER: NLM
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