Publication related to RSI or an RSI staff member
Can shape analysis differentiate free-floating internal carotid artery thrombus from atherosclerotic plaque in patients evaluated with CTA for stroke or transient ischemic attack?
Authors
- Thornhill, Rebecca E, Thornhill RE, Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada; Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Ave, Ottawa, Ontario K1Y 4E9, Canada; Clinical Epidemiology Program/Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Electronic address: rthornhi@gmail.com.
- Lum, Cheemun, Lum C, Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada; Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Ave, Ottawa, Ontario K1Y 4E9, Canada; Clinical Epidemiology Program/Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
- Jaberi, Arash, Jaberi A, Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada; Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Ave, Ottawa, Ontario K1Y 4E9, Canada.
- Stefanski, Pawel, Stefanski P, Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada; Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Ave, Ottawa, Ontario K1Y 4E9, Canada.
- Torres, Carlos H, Torres CH, Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada; Department of Medical Imaging, The Ottawa Hospital, 1053 Carling Ave, Ottawa, Ontario K1Y 4E9, Canada; Clinical Epidemiology Program/Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
- Momoli, Franco, Momoli F, Clinical Epidemiology Program/Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
- Petrcich, William, Petrcich W, Clinical Epidemiology Program/Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
- Dowlatshahi, Dar, Dowlatshahi D, Clinical Epidemiology Program/Methods Centre, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Division of Neurology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
YEAR OF PUBLICATION: 2014
SOURCE: Acad Radiol. 2014 Mar;21(3):345-54. doi: 10.1016/j.acra.2013.11.011.
JOURNAL TITLE ABBREVIATION: Acad Radiol
JOURNAL TITLE: Academic radiology
ISSN: 1878-4046 (Electronic) 1076-6332 (Linking)
VOLUME: 21
ISSUE: 3
PAGES: 345-54
PLACE OF PUBLICATION: United States
ABSTRACT:
RATIONALE AND OBJECTIVES: Patients presenting with transient ischemic attack or stroke may have symptom-related lesions on acute computed tomography angiography (CTA) such as free-floating intraluminal thrombus (FFT). It is difficult to distinguish FFT from carotid plaque, but the distinction is critical as management differs. By contouring the shape of these vascular lesions ("virtual endarterectomy"), advanced morphometric analysis can be performed. The objective of our study is to determine whether quantitative shape analysis can accurately differentiate FFT from atherosclerotic plaque. MATERIALS AND METHODS: We collected 23 consecutive cases of suspected carotid FFT seen on CTA (13 men, 65 +/- 10 years; 10 women, 65.5 +/- 8.8 years). True-positive FFT cases (FFT+) were defined as filling defects resolving with anticoagulant therapy versus false-positives (FFT-), which remained unchanged. Lesion volumes were extracted from CTA images and quantitative shape descriptors were computed. The five most discriminative features were used to construct receiver operator characteristic (ROC) curves and to generate three machine-learning classifiers. Average classification accuracy was determined by cross-validation. RESULTS: Follow-up imaging confirmed sixteen FFT+ and seven FFT- cases. Five shape descriptors delineated FFT+ from FFT- cases. The logistic regression model produced from combining all five shape features demonstrated a sensitivity of 87.5% and a specificity of 71.4% with an area under the ROC curve = 0.85 +/- 0.09. Average accuracy for each classifier ranged from 65.2%-76.4%. CONCLUSIONS: We identified five quantitative shape descriptors of carotid FFT. This shape "signature" shows potential for supplementing conventional lesion characterization in cases of suspected FFT.
RATIONALE AND OBJECTIVES: Patients presenting with transient ischemic attack or stroke may have symptom-related lesions on acute computed tomography angiography (CTA) such as free-floating intraluminal thrombus (FFT). It is difficult to distinguish FFT from carotid plaque, but the distinction is critical as management differs. By contouring the shape of these vascular lesions ("virtual endarterectomy"), advanced morphometric analysis can be performed. The objective of our study is to determine whether quantitative shape analysis can accurately differentiate FFT from atherosclerotic plaque. MATERIALS AND METHODS: We collected 23 consecutive cases of suspected carotid FFT seen on CTA (13 men, 65 +/- 10 years; 10 women, 65.5 +/- 8.8 years). True-positive FFT cases (FFT+) were defined as filling defects resolving with anticoagulant therapy versus false-positives (FFT-), which remained unchanged. Lesion volumes were extracted from CTA images and quantitative shape descriptors were computed. The five most discriminative features were used to construct receiver operator characteristic (ROC) curves and to generate three machine-learning classifiers. Average classification accuracy was determined by cross-validation. RESULTS: Follow-up imaging confirmed sixteen FFT+ and seven FFT- cases. Five shape descriptors delineated FFT+ from FFT- cases. The logistic regression model produced from combining all five shape features demonstrated a sensitivity of 87.5% and a specificity of 71.4% with an area under the ROC curve = 0.85 +/- 0.09. Average accuracy for each classifier ranged from 65.2%-76.4%. CONCLUSIONS: We identified five quantitative shape descriptors of carotid FFT. This shape "signature" shows potential for supplementing conventional lesion characterization in cases of suspected FFT.
COPYRIGHT INFORMATION: Copyright (c) 2014 AUR. Published by Elsevier Inc. All rights reserved.
LANGUAGE: eng
DATE OF PUBLICATION: 2014 Mar
DATE COMPLETED: 20141022
DATE REVISED: 20161125
MESH DATE: 2014/10/23 06:00
EDAT: 2014/02/11 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: S1076-6332(13)00544-8 [pii] 10.1016/j.acra.2013.11.011 [doi]
OWNER: NLM
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