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A decision tree approach to screen drinking water contaminants for multiroute exposure potential in developing guideline values.
The consideration of inhalation and dermal routes of exposures in developing guideline values for drinking water contaminants is important. However, there is no guidance for determining the eligibility of a drinking water contaminant for its multiroute exposure potential. The objective of the present study was to develop a 4-step framework to screen chemicals for their dermal and inhalation exposure potential in the process of developing guideline values. The proposed framework emphasizes the importance of considering basic physicochemical properties prior to detailed assessment of dermal and inhalation routes of exposure to drinking water contaminants in setting guideline values.
Authors
- Krishnan, Kannan, Krishnan K, Risk Sciences International, Ottawa, Ontario, Canada
- Carrier, Richard, Carrier R, Water and Air Quality Bureau, Health Canada, Ottawa, Ontario, Canada
YEAR OF PUBLICATION: 2017 July 3
JOURNAL TITLE ABBREVIATION: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
JOURNAL TITLE: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
ISSN: 1532-4095
VOLUME: 35
ISSUE: 3
PAGES: 173-187
ABSTRACT:
The consideration of inhalation and dermal routes of exposures in developing guideline values for drinking water contaminants is important. However, there is no guidance for determining the eligibility of a drinking water contaminant for its multiroute exposure potential. The objective of the present study was to develop a 4-step framework to screen chemicals for their dermal and inhalation exposure potential in the process of developing guideline values. The proposed framework emphasizes the importance of considering basic physicochemical properties prior to detailed assessment of dermal and inhalation routes of exposure to drinking water contaminants in setting guideline values.
The consideration of inhalation and dermal routes of exposures in developing guideline values for drinking water contaminants is important. However, there is no guidance for determining the eligibility of a drinking water contaminant for its multiroute exposure potential. The objective of the present study was to develop a 4-step framework to screen chemicals for their dermal and inhalation exposure potential in the process of developing guideline values. The proposed framework emphasizes the importance of considering basic physicochemical properties prior to detailed assessment of dermal and inhalation routes of exposure to drinking water contaminants in setting guideline values.
LANGUAGE: English
DATE OF PUBLICATION: 2017 July 3
DATE OF ELECTRONIC PUBLICATION: -
DATE REVISED: 2018 December 2
EDAT: 2017 June 6
STATUS: MEDLINE
PUBLICATION STATUS: Published in paper
PUBLISHING MODEL: Print