Each year the Society of Toxicology, Biological Modeling Specialty Section (BMSS) does a literature search to identify outstanding modeling papers in the field of toxicology.
The PubMed search identified well over 300 papers for drugs and chemicals. The list was reduced to approximately 60-70 in the general field of toxicology, and again reduced to 30+ papers with authors who have an SOT affiliation. Subsequently, a short list of 9 papers was selected, including the RSI paper on application of PBPK models in estimating human brain tissue manganese concentrations.
A copy of the paper is available here: Ramoju-2017-The application of PBPK models in estimating human brain tissue manganese concentrations.
The Society of Toxicology is a learned society based in the United States that supports scientific inquiry in the field of toxicology.
More RSI News
Aging and cognitive decline
Working with the College of Physicians and Surgeons of Alberta, Risk Sciences International conducted a wide-ranging review of aging and cognitive decline, with specific focus on aging physicians and fitness to practice. Â The publication in Aging & Mental Health documents domains of cognition that decline with older age, concerns with relying on physician self-reported competency, challenges with cognitive screening in older physicians, and a general data gap linking cognitive levels and fitness to practice.
Evidence-based Risk Assessment Framework
Working with international thought leaders in risk science, Risk Sciences International investigators contributed to the development of the evidenced-based risk assessment framework shown in the…
Food safety assessments
Problem Formulation in Food Safety Assessments conducted by the European Food Safety Authority RSI investigators recently provided advice to the European Food Safety Authority (EFSA)…
Value of information analysis framework
In its 2007 report on Toxicity Testing in the 21st Century: A Vision and a Strategy, the US National Research Council (NRC) highlighted need for more rapid…