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Maternal exposure to moderate ambient carbon monoxide is associated with decreased risk of preeclampsia.

OBJECTIVE: Carbon monoxide (CO) in cigarette smoke may be the mechanism by which tobacco use during pregnancy decreases the risk of the development of preeclampsia. We attempted to test this hypothesis by examining the effect of maternal exposure to ambient CO on preeclampsia. STUDY DESIGN: Births that occurred between 2004 and 2009 in the Canadian province of Ontario were extracted from the data. Study subjects were divided into 4 groups according to quartiles of CO concentration that were based on maternal residence. Adjusted odds ratio and 95% confidence interval were used to estimate the independent effect of CO on preeclampsia. RESULTS: Rates of preeclampsia were 2.32%, 1.97%, 1.59%, and 1.26%, respectively, in the first, second, third, and fourth quartile of CO concentration. The inverse association between CO concentration and preeclampsia risk remained the same after adjustment for several important confounding factors. CONCLUSION: Maternal exposure to moderate ambient CO is associated independently with a decreased risk of preeclampsia.

Authors

  • Zhai, Desheng, Zhai D, School of Public Health, Central South University, Changsha, Hunan, People's Republic of China.

  • Guo, Yanfang, Guo Y,

  • Smith, Graeme, Smith G,

  • Krewski, Daniel, Krewski D,

  • Walker, Mark, Walker M,

  • Wen, Shi Wu, Wen SW,

YEAR OF PUBLICATION: 2012
SOURCE: Am J Obstet Gynecol. 2012 Jul;207(1):57.e1-9. doi: 10.1016/j.ajog.2012.03.022. Epub 2012 Mar 29.
JOURNAL TITLE ABBREVIATION: Am J Obstet Gynecol
JOURNAL TITLE: American journal of obstetrics and gynecology
ISSN: 1097-6868 (Electronic) 0002-9378 (Linking)
VOLUME: 207
ISSUE: 1
PAGES: 57.e1-9
PLACE OF PUBLICATION: United States
ABSTRACT:
OBJECTIVE: Carbon monoxide (CO) in cigarette smoke may be the mechanism by which tobacco use during pregnancy decreases the risk of the development of preeclampsia. We attempted to test this hypothesis by examining the effect of maternal exposure to ambient CO on preeclampsia. STUDY DESIGN: Births that occurred between 2004 and 2009 in the Canadian province of Ontario were extracted from the data. Study subjects were divided into 4 groups according to quartiles of CO concentration that were based on maternal residence. Adjusted odds ratio and 95% confidence interval were used to estimate the independent effect of CO on preeclampsia. RESULTS: Rates of preeclampsia were 2.32%, 1.97%, 1.59%, and 1.26%, respectively, in the first, second, third, and fourth quartile of CO concentration. The inverse association between CO concentration and preeclampsia risk remained the same after adjustment for several important confounding factors. CONCLUSION: Maternal exposure to moderate ambient CO is associated independently with a decreased risk of preeclampsia.
COPYRIGHT INFORMATION: Crown Copyright (c) 2012. Published by Mosby, Inc. All rights reserved.
LANGUAGE: eng
DATE OF PUBLICATION: 2012 Jul
DATE OF ELECTRONIC PUBLICATION: 20120329
DATE COMPLETED: 20120827
DATE REVISED: 20131121
MESH DATE: 2012/08/28 06:00
EDAT: 2012/04/24 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: 10.1016/j.ajog.2012.03.022 [doi]
COMMENT IN:
OWNER: NLM

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Daniel Krewski

Chief Risk Scientist
Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...
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