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The power and interpretation of the carcinogenicity bioassay.
Carcinogenicity is a major consideration in the assessment of risks due to environmental chemicals. The carcinogen bioassay therefore is a very important component of the battery of toxicological tests used in hazard evaluation. The strengths and limitations of this bioassay are discussed with emphasis upon the unresolved practical considerations, the interpretation of negative results, the significance of tumors induced in the presence of a high background incidence of naturally occurring tumors, and the difficulties in transspecies extrapolation. These factors, in combination with consideration of the biological mechanisms of chemical cancer induction, will be valuable in assessing the potential risk to man posed by individual chemicals.
Authors
- Clayson, D B, Clayson DB,
- Krewski, D, Krewski D,
- Munro, I C, Munro IC,
YEAR OF PUBLICATION: 1983
SOURCE: Regul Toxicol Pharmacol. 1983 Dec;3(4):329-48. doi: 10.1016/0273-2300(83)90004-1.
JOURNAL TITLE ABBREVIATION: Regul Toxicol Pharmacol
JOURNAL TITLE: Regulatory toxicology and pharmacology : RTP
ISSN: 0273-2300 (Print) 0273-2300 (Linking)
VOLUME: 3
ISSUE: 4
PAGES: 329-48
PLACE OF PUBLICATION: Netherlands
ABSTRACT:
Carcinogenicity is a major consideration in the assessment of risks due to environmental chemicals. The carcinogen bioassay therefore is a very important component of the battery of toxicological tests used in hazard evaluation. The strengths and limitations of this bioassay are discussed with emphasis upon the unresolved practical considerations, the interpretation of negative results, the significance of tumors induced in the presence of a high background incidence of naturally occurring tumors, and the difficulties in transspecies extrapolation. These factors, in combination with consideration of the biological mechanisms of chemical cancer induction, will be valuable in assessing the potential risk to man posed by individual chemicals.
Carcinogenicity is a major consideration in the assessment of risks due to environmental chemicals. The carcinogen bioassay therefore is a very important component of the battery of toxicological tests used in hazard evaluation. The strengths and limitations of this bioassay are discussed with emphasis upon the unresolved practical considerations, the interpretation of negative results, the significance of tumors induced in the presence of a high background incidence of naturally occurring tumors, and the difficulties in transspecies extrapolation. These factors, in combination with consideration of the biological mechanisms of chemical cancer induction, will be valuable in assessing the potential risk to man posed by individual chemicals.
LANGUAGE: eng
DATE OF PUBLICATION: 1983 Dec
DATE COMPLETED: 19840215
DATE REVISED: 20191031
MESH DATE: 1983/12/01 00:01
EDAT: 1983/12/01 00:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
OWNER: NLM
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Chief Risk Scientist
Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...