Publication related to RSI or an RSI staff member
Overview of biological mechanisms of human carcinogens.
This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.
Authors
- Birkett, Nicholas, Birkett N, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
- Al-Zoughool, Mustafa, Al-Zoughool M, Department of Community and Environmental Health, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
- Bird, Michael, Bird M, McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
- Baan, Robert A, Baan RA, International Agency for Research on Cancer, Lyon, France.
- Zielinski, Jan, Zielinski J, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
- Krewski, Daniel, Krewski D, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Canada.; Risk Sciences International, Ottawa, Canada.
YEAR OF PUBLICATION: 2019
SOURCE: J Toxicol Environ Health B Crit Rev. 2019;22(7-8):288-359. doi: 10.1080/10937404.2019.1643539. Epub 2019 Oct 20.
JOURNAL TITLE ABBREVIATION: J Toxicol Environ Health B Crit Rev
JOURNAL TITLE: Journal of toxicology and environmental health. Part B, Critical reviews
ISSN: 1521-6950 (Electronic) 1093-7404 (Linking)
VOLUME: 22
ISSUE: 7-8
PAGES: 288-359
PLACE OF PUBLICATION: England
ABSTRACT:
This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.
This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.
LANGUAGE: eng
DATE OF PUBLICATION: 2019
DATE OF ELECTRONIC PUBLICATION: 20191020
DATE COMPLETED: 20200519
DATE REVISED: 20250530
MESH DATE: 2020/05/20 06:00
EDAT: 2019/10/22 06:00
STATUS: MEDLINE
PUBLICATION STATUS: ppublish
LOCATION IDENTIFIER: 10.1080/10937404.2019.1643539 [doi]
OWNER: NLM
Related RSI Experts
Chief Risk Scientist
Dr. Daniel Krewski is Chief Risk Scientist and co-founder of Risk Sciences International (RSI), a firm established in 2006 to bring evidence-based, multidisciplinary expertise to the challenge of understanding, managing, and communicating risk. As RSI’s inaugural CEO and long-time scientific...
Senior Toxicologist
Dr. Al-Zoughool has maintained a long-standing relationship with Risk Sciences International, both as a scientific collaborator and as a co-investigator on complex international projects. His work with RSI focuses on high-level public health risk modeling, mechanistic data analysis, and toxicological...