Value of information analysis framework

In its 2007 report on Toxicity Testing in the 21st Century: A Vision and a Strategy, the US National Research Council  (NRC) highlighted need for more rapid toxicity testing strategies in order to expand the coverage of the large number of chemicals for which toxicological data is lacking.

This need was further underscored by the NRC in its 2009 report Science and Decision: Advancing Risk Assessment, which recommended the use of formal value-of-information (VOI) techniques to evaluate alternative testing strategies.  Hagiwara et al. (2022) recently developed VOI methods to evaluate the trade-offs between the cost, timeliness, and uncertainty reduction in toxicity testing. 

These contributions suggest that while rapid alternative test methods may be subject to greater uncertainty than traditional more expensive animal tests of longer duration, having sufficient information to support risk decision making in a timely manner can result in a lower total social cost by avoiding pubic health impacts that can accrue when decisions are delayed pending the results of toxicity tests of longer duration.  Although further VOI analyses are needed to reaffirm these findings under broader real-world toxicity testing scenarios, initial results appear to be supportive of alternative test methods that can provide cost-effective toxicity data in a timely manner.

VOI paper in Risk Analysis
Steps and information flows in determining the value of information of toxicity testing strategies

Posted in

More RSI News

Principles of risk decision-making

August 19, 2022
RSI logo in white

RSI investigators propose fundamental principles of risk decision-making, and explore their application in a range of real-world risk decision-making contexts. These ten principles will provide valuable guidance on addressing current and future risk issues facing civil societies worldwide.

Read News Item

Risk of Myocarditis and Pericarditis

May 11, 2022
RSI logo in white

Using data from the US Centers for Disease Control (CDC) Vaccine Adverse Event Reporting System, RSI investigators collaborated on a study showing increased risks of…

Read News Item

Quinolones and risk of retinal detachment

April 26, 2022

Following previous work on the potential risk of acute liver failure associated with quinolone antibiotics, RSI investigators, Mohamed Taher, Franco Momoli, Donald Mattison and Daniel…

Read News Item

IAI climate change report

April 12, 2022
IAI Climate Change report

The International Aluminium Institute (IAI) recently commissioned Climate Risk Institute (CRI) and Risk Sciences International (RSI) to produce a series of informational tools evaluating and…

Read News Item