Adverse effects of drugs among the elderly should be given special attention when considering a pharmacological intervention.
Two recent papers using large electronic health records have explored the impact of drugs with anticholinergic properties.
The first, “Associations between Anticholinergic Burden and Adverse Health Outcomes in Parkinson Disease” view here used a HealthFacts database (Cerner Corporation, Kansas City, Missouri, USA) composed of 16,302 patients with Parkinson disease.
The second “Anticholinergic drugs and risk of dementia: case-control study” view here utilized 14,453 patients with dementia and 86,403 controls from the UK Clinical Practice Research Datalink.
Both studies observed a robust relationship between the use of drugs with anticholinergic properties and adverse consequences, including dementia, increased risks of visit to emergency departments and risk of fracture. Both studies demonstrate the importance of large electronic health record systems in understanding adverse drug events.
More RSI News
RSI Chief Medical Officer, Dr. Donald R. Mattison, in collaboration with colleagues from the Institute for Safe Medication Practices and Wake Forest University, evaluated and…
Read News Item
RSI recently conducted an in-house training session in systematic review for its staff. The session featured a keynote presentation by Dr. Katya Tsaioun from Johns…
Read News Item
RSI was contracted by CBS to assist the Alliance of Blood Operators in the development of a blood-safety oriented risk-based decision-making framework. Why use this…
Read News Item
2017 was a record-setting year for devastating wildfires across Canada and throughout the world. The Weather Network spoke to Heather Auld, principal climate scientist about…
Read News Item