Problem Formulation in Food Safety Assessments conducted by the European Food Safety Authority
RSI investigators recently provided advise to the European Food Safety Authority (EFSA) on the problem formulation step in the EFSA scientific assessment approach shown in the figure below. The recommended problem formulation framework is designed to translate the mandate into well-formulated assessment questions and sub-questions, and select the methodological approach to be used in the assessment. Over 700 EFSA scientific assessments conducted over the last two years were examined during the course of developing RSI’s recommendations to EFSA. A novel aspect of the suggested approach was parsing the questions and sub-questions into an APRIO paradigm based on the agent (A), pathway (P), receptor(R), intervention (I) and output (O).

EFSA scientific assessment approach
Posted in RSI News
More RSI News
RSI launches Global Risk Census
Risk Sciences International has launched The Global Risk Census. The goal of the Census is to provide insights into important risks that need to be…
Read News ItemUS FDA FAERS and quinolones
Some case reports on Quinolones, a potent and globally popular group of antibiotics that are used to treat a wide range of infections, have raised…
Read News ItemAdvancing Toxicity Testing webinar
The Center for Alternatives to Animal Testing and the Animal-Free Safety Assessment recently held their annual meeting on advancing toxicity testing in the 21st century…
Read News ItemUSC appoints Dr. Mattison distinguished professor
Dr. Donald Mattison, RSI’s Senior Vice-President and Chief Medical Officer, has accepted an appointment as a University of South Carolina Health Sciences Distinguished Professor in the in…
Read News Item